Vaccine against tyrpanosomiasis
OwnerRoger K. Prichard, George W Lubega +2inventors
InventorsRoger K. Prichard, George W Lubega, Denis K Byarugaba, Donosian O K Ochola
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Abstract
The present invention relates to the immunization of animals and humans with trypanosome tubulin to protect against trypanosomes. More particularly, the present invention relates to a substantially pure tubulin preparation, which comprises a tubulin extract from Trypanosoma brucei which tubulin preparation can protect animals and humans against heterologous strains of different species of Trypanosoma.
Claims11
A substantially pure tubulin preparation, which comprises a tubulin extract from Trypanosoma brucei, wherein said tubulin preparation can protect animals and humans against heterologous strains of different species of Trypanosoma.
A method for the immunization of an animal or a human patient against heterologous strains of different species of Trypanosoma, which comprises administering to said animal or human patient an immunogenic amount of a tubulin extract preparation isolated from a Trypanosoma.
A vaccine for immunizing animals or humans against trypanosomiasis, which comprises an immunogenic amount of a tubulin extract preparation isolated from a Trypanosoma or an immunoprotective amount of an antibody raised against a tubulin isolated from a Trypanosoma.
A vaccine for immunizing against trypanosomiasis in animals or humans, which comprises an immunogenic amount of a recombinant tubulin which corresponds in composition to a tubulin extract preparation isolated from a Trypanosoma or an immunoprotective amount of an antibody raised against said recombinant tubulin.
A vaccine for immunizing against trypanosomiasis in animals or humans, which comprises an immunogenic amount of a synthetic peptide which corresponds in composition to portion of an amino acid sequence of a tubulin extracted from a Trypanosoma or an immunoprotective amount of an antibody raised against said tubulin peptide.
Dependencies are inferred from the claim text.