TB diagnostic based on antigens from M. tuberculosis
AssigneeStatens Serum Institut
InventorsPeter Andersen, Karin Weldingh, Christina Veggerby Hansen, Walter Florio, Li Mei Meng Okkels, Rikke Louise Vinther Skjot, Peter Birk Rasmussen
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Abstract
The present invention is based on the identification and characterization of a number of novel M. tuberculosis derived proteins and protein fragments. The invention is directed to the polypeptides and immunologically active fragments thereof, the genes encoding them, immunological compositions such as diagnostic reagents containing the polypeptides.
Claims17
A composition comprising a combination of two or more substantially pure polypeptides, which comprises one or more amino acid sequences selected from
- a) Rv0652, Rv2462c, Rv1984c, Rv2185c, Rv1636, Rv3451, Rv3872, Rv3354 and Rv2623
- b) an immunogenic portion of any one of the sequences in (a);
- and/or
- c) an amino acid sequence analogue having at least 70% sequence identity to any one of the sequences in (a) or (b) and at the same time being immunogenic;
- for use as a pharmaceutical or diagnostic reagent.
A diagnostic tool comprising a combination of two or more substantially pure polypeptides, which comprises one or more amino acid sequences selected from
- (a) Rv0652, Rv2462c, Rv1984c, Rv2185c, Rv1636, Rv3451, Rv3872, Rv3354 and Rv2623
- (b) an immunogenic portion of any one of the sequences in (a);
- and/or
- (c) an amino acid sequence analogue having at least 70% sequence identity to any one of the sequences in (a) or (b) and at the same time being immunogenic
A serodiagnostic composition comprising a combination of two or more substantially pure polypeptides, which comprises one or more amino acid sequences selected from
- (a) Rv0652, Rv2462c, Rv1984c, Rv2185c, Rv1636, Rv3451, Rv3872, Rv3354 and Rv2623;
- (b) an immunogenic portion of any one of the sequences in (a);
- and/or
- (c) an amino acid sequence analogue having at least 70% sequence identity to any one of the sequences in (a) or (b) and at the same time being immunogenic.
Dependencies are inferred from the claim text.