Immunotherapeutic stress protein-peptide complexes against cancer
AssigneeMount Sinai School of Medicine of New York University
InventorPramod K. Srivastava
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Abstract
Disclosed is a method for inhibiting the proliferation of a tumor in a mammal. The method involves the steps of (a) isolating a stress protein-peptide complex from tumor cells previously removed from the mammal and (b) administering the isolated stress protein-peptide complex back to the mammal in order to stimulate in the mammal an immune response against the tumor from which the complex was isolated. Stress protein-peptide complexes having particular utility in the practice of the instant invention include the Hsp70-peptide, Hsp90-peptide and gp96-peptide complexes.
Claims18
A method for inhibiting proliferation of a tumor in a mammal, the method comprising:
- administering to the mammal harboring the tumor a composition comprising,
- (a) an immunogenic stress protein-peptide complex isolated from a cell derived from the tumor, said complex being operative to initiate in the mammal an immune response against said tumor, and
- (b) a pharmaceutically acceptable carrier,
- in an amount sufficient to elicit in the mammal an immune response against the tumor thereby inhibiting proliferation of the tumor.
A method for inhibiting proliferation of a tumor in a mammal, the method comprising the steps of:
- (a) providing a tumor cell excised from the mammal,
- (b) isolating from the cell an immunogenic stress protein-peptide complex operative to initiate in the mammal an immune response against the tumor cell, and
- (c) administering to the mammal the isolated stress protein-peptide complex in an amount sufficient to elicit in the mammal an immune response against the tumor cell thereby to inhibit proliferation of any tumor cell remaining in the mammal.
Dependencies are inferred from the claim text.