Novel bee venom polypeptides and methods of use thereof
AssigneeEcole Polytechnique Federale de Lausanne, Direction de la plantification et de la Recherche
InventorFrancois Spertini
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Abstract
The present invention provides novel protein named Api m 6. Api m 6 was identified in bee venom and is found in four isoforms, each about 8 kD. The purified Api m 6 can be used to modulate immune responses, e.g., in individuals hypersensitive to bee venom.
Claims14
A method of modulating an immune response, said method comprising administering a substantially pure polypeptide comprising an amino acid sequence at least 70% identical to the amino acid sequence of SEQ ID NO:4 to a subject in need thereof in an amount sufficient to inhibit an immune reaction by the subject against said polypeptide.
A method of modulating an immune response, said method comprising administering a substantially pure polypeptide comprising a fragment of the amino acid sequence of SEQ ID NO:4 to a subject in need thereof in an amount sufficient to inhibit an immune reaction by the subject against said polypeptide.
A method of modulating an immune response, said method comprising administering one or more substantially pure polypeptides wherein said one or more polypeptides comprise fragments of the amino acid sequence of SEQ ID NO:4 to a subject in need thereof, in an amount sufficient to inhibit an immune reaction by the subject against said one or more polypeptides.
Dependencies are inferred from the claim text.