Back to results
US 2003/0165506 A1Published application
Novel alpha-catenin expressed in heart and testis
AssigneeVlaams Interuniversitair Instituut Voor Biotechnologie VZW
InventorsFrans Van Roy, Steven Goossens, Barbara Janssens, Griet Vanpoucke
Life of this patent
Estimating the term…
Abstract
The present invention relates to a novel α-catenin with a new, specific expression pattern in mainly heart and testis. The invention further relates to the use of this α-catenin in the prediction, diagnosis, and/or treatment of cadherin-catenin related diseases, in particular cardiomyopathies and male infertility.
Claims24
An isolated polypeptide comprising the sequence presented in SEQ ID NO:
- 2, or a variant thereof, which variant has at least 70% identity with said sequence.
A method of diagnosing and/or predicting the likelihood of developing cadherin-catenin related diseases in a subject, the method comprising:
- using a BAC or a PAC selected from the group consisting of those with accession numbers BAC 162A20, AC009037, AC026394, AC027668, AC026394, AC022401, AC022534, AQ163827, AC020642, AQ351427, AQ355080, AC023847, AC027668, AC016819, AC027675, AC022024, AC021888, AC022017, AL592075, AP001355, AL513126, AC022017, AL513126, AC018979, PAC 320B7, or a fragment thereof or a mixture of any thereof, in the diagnosis of and/or predicting the likelihood of developing cadherin-catenin related diseases in the subject.
Dependencies are inferred from the claim text.