Compositions and methods for the therapy and diagnosis of ovarian cancer
AssigneeCorixa Corporation
InventorsMarc W. Retter, Gary R. Fanger
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Abstract
Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
Claims11
An isolated O8E polypeptide comprising a sequence set forth in any one of SEQ ID NOs:
- 392 and 393 or a fragment thereof that binds an antibody having specificity for a sequence set forth in any one of SEQ ID NOs:
- 392 and 393.
An antibody epitope of O8E wherein said antibody epitope is selected from the group consisting of amino acid residues 61-80 of SEQ ID NO:
- 392 and amino acid residues 151-170 of SEQ ID NO:
- 392.
An O8E peptide that binds HLA-A2 wherein said O8E peptide is selected from the group consisting of SEQ ID NOs:416-455.
An isolated O772P polypeptide comprising a sequence set forth in any one of SEQ ID NOs:
- 312, 388, 389 and 390, or a fragment thereof that binds an antibody having specificity for a sequence set forth in any one of SEQ ID NOs:
- 312, 388, 389 and 390.
Dependencies are inferred from the claim text.