Single-chain antibodies against human insulin-like growth factor I receptor: expression, purification, and effect on tumor growth
AssigneeCity of Hope
InventorYoko Fujita-Yamaguchi
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Abstract
A method of inhibiting the growth of hormone dependent tumor cells in a mammal comprises administering to said mammal an insulin-like growth factor receptor (IGF-IR) recombinant antibody, wherein said antibody can be a single-chain recombinant antibody, which can be humanized, capable of blocking agonist interaction with the IGF-IR.
Claims10
An IGF-IR antagonist comprising a recombinant single-chain antibody capable of effectively inhibiting IGF-IR-agonist interaction.
An IGF-IR single-chain recombinant antibody capable of effectively inhibiting IGF-IR-agonist interaction wherein the recombinant antibody consists essentially of a VL domain antigen binding portion linked to a VH domain antigen binding portion through a peptide linker.
Dependencies are inferred from the claim text.