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US 2003/0165498 A1Published application
Composite antibodies of humanized human subgroup IV light chain capable of binding to TAG-72
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsPeter S. Mezes, Ruth A. Richard, Kimberly S. Johnson, Jeffrey Schlom, Syed V.S. Kashmiri, Liming Shu, Eduardo A. Padlan
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Abstract
Novel composite and humanized anti-TAG-72 monoclonal antibodies, antibody fragments, and derivatives thereof using human subgroup IV kappa light chain framework regions.
Claims25
A humanized or composite anti-TAG-72 antibody or anti-TAG-72 antibody fragment which comprises a CDR-grafted light chain having non-human CDRs grafted to a human subgroup IV kappa light chain.
Dependencies are inferred from the claim text.