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AssigneeMillennium Pharmaceuticals, Inc.
InventorsRosana Kapeller-Libermann, David White, Inmaculada Silos-Santiago
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The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.
An isolated nucleic acid molecule having a nucleotide sequence selected from the group consisting of:
A method for producing a polypeptide encoded by a human nucleic acid molecule having at least about 80% sequence identity to SEQ ID NO:2, wherein the nucleotide sequence encodes a polypeptide having endopeptidase activity;
A method for producing a polypeptide encoded by a human nucleic acid molecule having at least about 90% sequence identity to SEQ ID NO:2, wherein the nucleotide sequence encodes a polypeptide having endopeptidase activity;
A method for producing a polypeptide encoded by a human nucleic acid molecule having at least about 95% sequence identity to SEQ ID NO:2, wherein the nucleotide sequence encodes a polypeptide having endopeptidase activity;
A kit comprising reagents for use in a method for detecting the presence of a nucleotide sequence selected from the group consisting of:
Dependencies are inferred from the claim text.