Method of treating rhinitis or sinusitis
AssigneeB.M.R.A. Corporation B.V.
InventorsEric Grouzmann, Jean-Silvain Lacroix, Michel Monod
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Abstract
The present invention is directed to methods of treating mucosal inflammation associated with rhinitis or sinusitis by administering peptidases that recognize and cleave polypeptides at Xaa-Pro sequences. In addition, the invention encompasses therapeutic packages in which pharmaceutical compositions containing the peptidases are preloaded in a device suitable for intranasally delivering drug.
Claims16
A method of treating a patient for mucosal inflammation associated with rhinitis, sinusitis or both, comprising:
- intranasally administering to said patient a therapeutically effective amount of a peptidase that cleaves at Xaa-Pro sequences.
A therapeutic package comprising a device for intranasally delivering drug to a patient, preloaded with a solution or powder comprising a peptidase that cleaves at Xaa-Pro sequences.
A method of treating a patient for mucosal inflammation associated with rhinitis, sinusitis or both, comprising:
- intranasally administering to said patient a therapeutically effective amount of an agent that inhibits the binding of SP to the NK1 receptor.
Dependencies are inferred from the claim text.