Amyloid peptide inactivating enzyme to treat Alzheimer's disease
OwnerLouis B. Hershinventor
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Abstract
Estrogen has been shown to increase the expression and activity of amyloid peptide inactivating enzymes in the brain. Peptides have been shown to increase the activity of an amyloid peptide inactivating enzyme. A method of treating patients with Alzheimer's Disease is disclosed.
Claims29
A method for preventing formation or growth of amyloid plaque without causing neurotoxicity, comprising:
- a) generating a recombinant viral or plasmid vector comprising a DNA sequence encoding at least one amyloid peptide inactivating enzyme operatively linked to a promoter;
- b) transfecting in vitro a population of cultured neural cells or fibroblasts;
- with said recombinant vector, resulting in a population of transfected neural cells or fibroblasts;
- and
- c) transplanting said transfected neural cells or fibroblasts;
- by injection to the brain of a mammalian host, such that expression of said DNA sequence within said brain results in inactivation of said amyloid peptides.
A method for preventing formation or growth of amyloid plaque without causing neurotoxicity, comprising:
- a) generating a recombinant viral or plasmid vector comprising a DNA sequence encoding an amyloid peptide inactivating enzyme operatively linked to a promoter;
- and
- b) injecting said vector to the brain of a mammalian host, such that expression of said DNA sequence within said brain results in inactivation of said amyloid peptides.
A method for preventing formation or growth of amyloid plaque without causing neurotoxicity, comprising:
- a) generating and purifying recombinant amyloid peptide inactivating enzyme and
- b) injecting said amyloid peptide inactivating enzyme to the brain via a pump delivery system.
A method for preventing formation or growth of amyloid plaque without causing neurotoxicity, comprising administering to a patient in need thereof a compound that enhances the expression of the amyloid inactivating enzyme.
A method for treating Alzheimer's disease comprising administering to a patient in need thereof a pharmaceutically effective amount of a compound that enhances the expression of an amyloid inactivating enzyme.
A method for treating Alzheimer's disease comprising administering to a patient in need thereof a pharmaceutically effective amount of an amyloid peptide inactivating enzyme.
A method for increasing the activity of an amyloid inactivating enzyme comprising, administering to a patient in need thereof a pharmaceutically effective amount of a compound that increases the activity of the amyloid inactivating enzyme.
Dependencies are inferred from the claim text.