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US 2003/0165469 A1Published application
Construction of high efficiency retroviral vector for gene therapy of hunter syndrome
AssigneeViroMed Co., Ltd.
InventorsSunyoung Kim, Seung Shin Yu, Youngtae Hong, Jong-Mook Kim, Eun Young Han
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Abstract
The present invention provides a retroviral vector containing an iduronate-2-sulfatase (IDS) gene but without selective marker gene, constructed on, as a backbone, a minimum sized MLV-based retroviral vector which does not contain any viral coding sequences but can still produce a high viral titer and drive a high level of gene expression.
Claims6
A retroviral vector comprising an iduronate-2-sulfatase (IDS) gene and the backbone of a minimum sized MLV-based retroviral vector lacking any viral coding sequence, the retroviral vector containing no selective marker gene.
Dependencies are inferred from the claim text.