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US 2003/0165460 A1Published application
Methods of modulating il- 174 response
AssigneeSchering Corporation
InventorsStephen D. Hurst, Sandra M. Zurawski, Donna M. Rennick
Life of this patent
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Abstract
Agonists or antagonists of cytokine designated IL-174, and various methods of their use are provided. In particular, the methods make use of facts that many activities of the IL-174 cytokine are described.
Claims14
A method of:
- a) directing a mammalian immune response towards a Th2 type response, said method comprising administering an IL-174 agonist to immune cells of the mammal;
- b) stimulating an mammalian innate immune response, said method comprising administering an IL-174 agonist to immune cells of the mammal;
- c) augmenting a mammalian inflammatory response from epithelial or fibroblast cells, said method comprising further administering an IL-174 agonist to said mammal;
- d) inducing gut cell growth, said method comprising administering an IL-174 agonist to said cell;
- e) promoting mammalian extra medulary hematopoiesis, said method comprising administering an IL-174 agonist to said mammal;
- f) directing a mammalian immune response away from a Th2 type response, said method comprising administering an IL-174 antagonist to immune cells of the mammal;
- g) preventing mammalian inflammation or granuloma formation, comprising administering an IL-174 antagonist to immune system cells;
- or
- h) augmenting antibody response in serum and fecal material, said method comprising administering an IL-174 agonist to immune cells of the mammal.
6 more elements
A composition comprising:
- a) an IL-174 agonist and:
- i) an antimicrobial, including an antibiotic, antiviral, or antifungal compound;
- or
- ii) a chemotherapy agent;
- or
- b) an IL-174 antagonist and:
- i) an allergy medicament;
- ii) an asthma medicament;
- iii) a dermatitis medicament;
- iv) a fibrosis medicament;
- or
- v) an eosinophilic gastritis medicament.
9 more elements
Dependencies are inferred from the claim text.