Formulations for use in inhaler devices
AssigneeVectura Limited
InventorsJohn Nicholas Staniforth, David Alexander Vodden Morton
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Abstract
A formulation for use in an inhaler device comprises carrier particles having a diameter of at least 50 μm and a mass median diameter of at least 175 μm; fine particles of an excipient material having a mass median aerodynamic diameter of not more than 20 μ; and active particles. The formulation has excellent flowability even at relatively high contents of fine particles.
Claims44
A formulation for use in-an inhaler device, comprising
- carrier particles having a diameter of at least 50 μm and a mass median diameter of at least 175 μm;
- fine particles of an excipient material having a mass median aerodynamic diameter of not more than 20 μm;
- and active particles.
A formulation for use in a dry powder inhaler, comprising more than 5% by weight, based on the total weight of the formulation, of particles of aerodynamic diameter less than 20 μm, the formulation having a flowability index of 12 mm or less.
A formulation for use in an inhaler device, comprising:
- from 5 to 90% by weight carrier particles having a diameter of at least 50 μm and a mass median diameter of at least 175 μm;
- from 0.01 to 80% by weight of a therapeutically active agent;
- from 9 to 50% by weight of particles of fine excipient material of diameter less than 50 μm;
- in each case, by weight, based on the total weight of the carrier particles, active agent and fine excipient material.
A formulation substantially as described herein.
A formulation substantially as described in any of Examples 1 to 3.
Dependencies are inferred from the claim text.