Stable pharmaceutical budesonide preparation for producing propellant-free aerosols
AssigneeBoehringer Ingelheim GmbH
InventorsBernhard Freund, Michael Krueger, Bernd Zierenberg
Life of this patent
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Abstract
The invention relates to ethanol-containing pharmaceutical preparations for the production of propellant-free aerosols.
Claims20
A pharmaceutical preparation for use in producing propellant-free aerosols which comprises a pharmacologically active substance, and if necessary, pharmacologically-harmless adjuvants and/or flavourings, characterised in that the pharmaceutical preparation contains at least 70% (v/v) ethanol as a solvent.
A pharmaceutical preparation for the production of propellant-free aerosols, comprising a steroid and, if necessary, pharmacologically-harmless adjuvants and/or flavourings, characterised in that the pharmaceutical preparation contains at least 85% (v/v) ethanol as a solvent, and if necessary, a complex forming agent.
A pharmaceutical preparation for use in producing a propellant-free metering aerosol containing, per 100 ml of 96% (v/v) ethanol, 1.667 g of Flunisolide hemihydrate and 1 mg of disodium EDTA, the pH value of the pharmaceutical preparation being adjusted to 4.0.
A pharmaceutical preparation for use in producing a propellant-free metering aerosol containing, per 100 ml of 90% (v/v) ethanol, 1.667 g of Flunisolide hemihydrate and 1 mg of disodium EDTA, the pH value of the pharmaceutical preparation being adjusted to 4.0.
A pharmaceutical preparation for use in producing a propellant-free metering aerosol containing, per 100 ml of 96% (v/v) ethanol, 1.333 g of Budesonide and 1 mg of disodium EDTA, the pH value of the pharmaceutical preparation being adjusted to 4.0.
A pharmaceutical preparation for use in producing a propellant-free metering aerosol containing, per 100 ml of 90% (v/v) ethanol, 1.333 g of Budesonide and 1 mg of disodium EDTA, the pH value of the pharmaceutical preparation being adjusted to 4.0.
Use of a pharmaceutical preparation comprising a pharmacologically active substance in a solution containing at least 79% ethanol by volume in the preparation of a propellant-free composition for administration by inhalation.
Dependencies are inferred from the claim text.