Tuftsin metallopeptide analogs and uses thereof
AssigneeRhomed Incorporated
InventorShubh D. Sharma
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Abstract
Tuftsin receptor-specific peptides, peptidomimetics and peptide-like constructs are provided, particularly for use in biological, pharmaceutical and radiopharmaceutical applications, in which the peptide, peptidomimetic or construct is conformationally fixed on complexation of the metal ion-binding portion thereof with a metal ion, resulting in a peptide, peptidomimetic or construct with increased affinity for the tuftsin receptor.
Claims22
A peptide comprising a metal ion-binding backbone including two or more contiguous amino acids available for complexing with a metal ion, which peptide is specific for the tuftsin receptor on complexing the metal ion-binding backbone with a metal ion.
A tuftsin receptor-specific antagonist peptide comprising the sequence D-Lys-Gly-D-Cys-Arg complexed with a metal ion.
A manufactured peptide and pharmaceutically acceptable salts thereof which is specific for the tuftsin receptor upon complexing with a metal ion, said peptide being of the general formula:
- R2-R3-Cys-R4
- wherein R2 comprises D- or L-Lys, Arg, Gly, Thr, Gln or Orn;
- wherein R3 is D- or L-Gly, Ser, Lys, Arg;
- wherein Cys is D-Cys or L-Cys;
- and
- wherein R4 comprises D- or L-Arg, Lys, Leu or Orn.
Dependencies are inferred from the claim text.