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US 2003/0165402 A1Published application
Biocidal protection system
OwnerAlex Sava, Steven Kritzlerinventors
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OwnerAlex Sava, Steven Kritzlerinventors
Estimating the term…
The invention relates to a shelf stable liquid disinfectant concentrate composition containing at least 1% by weight of a quat biocide (biocidally active quaternary ammonium compounds) and capable of dilution with 20 parts of water to 1 part of concentrate to produce a diluted solution, the diluted solution exhibiting a MIC after 24 hours in the presence of up to 2% tryptone (or the protein equivalent thereof) which is less than the MIC of a simple solution of the same concentration of the same quat biocide in water in the presence of the same concentration of the protein. The biocidal efficacy of the quat biocide may be protected by an “activity protector” selected from the group consisting of “enzyme stabilisers”, “enzyme stabilising systems”, micelle formation modifiers and inhibitors, and combinations thereof. The invention also relates to a disinfectant working solution prepared from the concentrate, and to a method of protecting a quat biocide from deactivation.
A shelf stable liquid disinfectant concentrate composition including:
A concentrate according to any one of the preceding claims wherein the quat biocide is a monomeric quaternary ammonium antimicrobial agent.
A concentrate according to any one of the preceding claims wherein the biocidal efficacy of the quat biocide is protected by an activity protector selected from the group consisting of boron compounds, polyols, formates, calcium ions, polyfunctional amino compounds, phosphates, citrates, sulphates and sequestering agents.
A concentrate according to any one of the preceding claims including a micelle immiscible solvent.
A concentrate according to the preceding claim wherein the micelle immiscible solvent is selected from the group consisting of C1-C 6 alkanols, C1-C 6 diols, C3-C 24 alkylene glycol ethers, alkylene glycol alky ethers, borates, lactates, citrates, tartrates and mixtures thereof.
A liquid disinfectant concentrate according to any one of the preceding claims which retains at least 75% of its biocidal efficacy after 12 months storage in a sealed container at 18-25° C.
A liquid disinfectant concentrate composition according to any one of the preceding claims which retains at least 90% of its biocidal efficacy after 12 months storage in a sealed container at 18-25° C.
A concentrate according to any one of the preceding claims including at least 10% by weight of quat biocide.
A concentrate according to any one of the preceding claims including at least 25% by weight of quat biocide.
A concentrate according to any one of the preceding claims such that when diluted by 20 parts of water to 1 part of concentrate, the diluted solution exhibits a MIC after 24 hrs in the presence of up to 2% of tryptone (or the protein equivalent thereof) which is less than 50% of the MIC of a simple solution of the same concentration of the same quat biocide in water in the presence the same concentration of the protein.
A concentrate according to any one of the preceding claims such that when diluted by 20 parts of water to 1 part of concentrate, the diluted solution exhibits a MIC after 24 hrs in the presence of up to 2% of tryptone (or the protein equivalent thereof) which is less than 40% of the MIC of a simple solution of the same concentration of the same quat biocide in water in the presence the same concentration of the protein.
A concentrate according to any one of the preceding claims further including at least one non ionic surfactant.
A concentrate according to any one of the preceding claims wherein the quat biocide is a monomeric quaternary ammonium antimicrobial compound selected from the group having a general formula:
A concentrate according to the preceding claim wherein X is chlorine or bromine.
A concentrate according to any one of the preceding claims wherein the quat biocide is selected from the group consisting of mono-long-alkyl chain, tri-short chain, tetralkyl ammonium compounds;
A concentrate according to the preceding claim wherein the quat biocide is selected from the group consisting of monoalkyltrimethyl ammonium salts, monoalkyldimethylbenzyl compounds, dialkylbenzyl compounds and quaternary gluconates
A concentrate according to any one of the preceding claims wherein the biocide is selected from the group consisting of C 8 to C 22 dimethyl benzyl ammonium chloride, C 8-C 22 dimethyl ethyl benzyl ammonium chloride and di-C 6-C 20 alkyl dimethyl ammonium chloride.
A concentrate according to any one of the preceding claims wherein the quat biocide is a benzyl dimethyl ammonium halide.
A concentrate according to the preceding claim wherein a stabiliser is selected from boric acid, boric oxide, borax, or sodium ortho-, meta-, or pyro-borate, perborates.
A concentrate according to the preceding claim wherein a stabiliser includes sodium tetraborate.
A concentrate according to any one of the preceding claims wherein the biocidal efficacy of the quat biocide is protected by a boron compound and further including a polyol having from 2 to 6 hydroxyl groups.
A concentrate according to the preceding claim wherein the polyol is selected from the group consisting of ethylene glycol, propylene glycol 1,2 propanediol, butyleneglycol and most preferably glycerol, mannitol, sorbitol, erythritol, glucose, fructose and lactose.
A concentrate according to any one of the preceding claims including a surfactant selected from the group consisting of nonionic surfactants and semipolar nonionic surfactants.
A concentrate according to any one of the preceding claims including nonyl phenol ethoxylate.
A concentrate according to any one of the preceding claims after dilution by more than 200 parts of water to 1 part of concentrate.
A concentrate according to any one of the preceding claims after dilution by more than 1000 parts of water to 1 part of concentrate.
A working solution of a disinfectant biocidally effective in the presence of a protein, said solution including:
A working solution of a disinfectant biocidally effective in the presence of a protein including:
A method of protecting a quat biocide from deactivation including the steps of combining the quat biocide with an “activity protector” selected from the group consisting of enzyme stabilisers and micelle destabilises or combinations thereof.
A method according to claim 64 wherein the activity protector is one or more substances selected from the group consisting of boron compounds, polyols, formates, calcium ions, polyfunctional amino compounds phosphates, citrates, sulphates and sequestering agents
A method according to claim 66 wherein the activity protector includes sodium tetraborate.
A disinfectant substantially as herein described with reference to example 1 or example 2.
Dependencies are inferred from the claim text.