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US 2003/0159166 A1Published application
H2-O modified transgenic animals
OwnerLars Karlsson, Wai-Ping Leung +2inventors
InventorsLars Karlsson, Wai-Ping Leung, Per A. Peterson, Christopher Alfonso
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Abstract
A transgenic animal with alterations in an H2-O gene is prepared by introduction of an altered H2-O gene into a host animal. The resulting transgenic animals produce a substantially greater frequency of high affinity antibodies compared to H2-O wild type animals. A method for the production of high affinity antibodies is disclosed.
Claims2
A method for the production of B-cells, comprising:
- a) immunizing an H2-O−/− mouse with a sufficient amount of an antigen to produce an immune response;
- and
- b) collecting B-cells from said immunized mouse.
A method for the production of antibodies, comprising:
- a) immunizing an H2-O−/− mouse with a sufficient amount of an antigen to cause antibody production;
- and
- b) collecting antibodies from said immunized mouse.
Dependencies are inferred from the claim text.