Caspase 1 gene transfer animal
AssigneesHitoshi Mizutani, Kenji Nakanishi, Taiho Pharmaceutical Co., Ltd.
InventorHitoshi Mizutani
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Abstract
A transgenic non-human mammal or its offspring which carries DNA having exogenous caspase 1 gene integrated thereinto in such a manner as to express the gene specifically to skin. In view that the transgenic non-human mammal of the present invention spontaneously develops atopic dermatitis in the absence of any specific pathogenic microorganism, the mammal is useful as a disease model animal. Use of the transgenic animal of the present invention enables development of preventive and/or therapeutic drugs for atopic dermatitis based on natural immunity and to clarify the onset mechanism of atopic diseases.
Claims8
A transgenic non-human mammal or its offspring comprising DNA having exogenous caspase 1 gene integrated thereinto so that the gene is skin-specifically expressed.
Dependencies are inferred from the claim text.