Systen and process for microfluidics-based automated chemistry
AssigneeMemorial Sloan Kettering Cancer Center
InventorsMichael Powell, Paul Tempst
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Abstract
System and process for performing complex reactions such as protein sequencing using small volumes and amounts of reagents, the system in part comprising the use of rotary type selector-switching value combinations.
Claims15
A system for carrying out one or more chemical reactions, said system comprising a rotary selector valve and a rotary switching valve, each valve under the control of a computer, the internal volumes of the selector and switching valves each being 1.5 μl or less.
A reaction process under the control of a computer said process comprising the steps of:
- 1) Delivering, from a reagent vessel under pressure from a gas source, a volume of a reagent via a delivery line to a reaction vessel wherein the total volume delivered for purposes of a reaction in the reaction vessel is in the range 0.5 μL to 10 μL, and wherein flow through the delivery line is under the control of a computer-controlled rotary switching valve connected to a rotary selector valve.
A rotary selector valve cascade in which a plurality of peripheral ports of a first selector valve are each connected to the central common port of one of a plurality of rotary selector valves that each comprise a plurality of peripheral ports, the total internal volume of each valve being 1.5 μL or less.
Dependencies are inferred from the claim text.