Radiolabeled solid surfaces and process for making them
OwnerChaim Sukenik, Harold Jacob +1inventors
InventorsChaim Sukenik, Harold Jacob, Marc Sheldon Berridge
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Abstract
A device, which comprises a surface layer that has incorporated therein at least one radioactive nuclide. The surface layer is a self-assembled layer, particularly an anchored SAM that is selected from the group consisting of monolayers or films anchored by siloxane, thiol, amine or phosphonate. The surface layer may be formed of a radioactive material that has been activated to induce radioactivity therein after its final formation. The device may comprise a chemically functionalized SAM incorporating radionuclides attached at the surface of the device. The device may be a temporary or permanent therapeutic implant, such as a stent.
Claims35
A device, which comprises a surface layer that has incorporated therein at least one radioactive nuclide.
A device which comprises a substrate and a self-assembled layer that has incorporated therein at least one radioactive nuclide.
8 A device according to claim 1, wherein the surface layer is formed of a radioactive material that has been activated to induce radioactivity therein after its final formation.
10 A device comprising a substrate covered on all its surfaces by a self-assembled layer, which layer includes radioactive nuclides, and having no other protective layer or coating over said self-assembled layer.
A temporary or permanent therapeutic implant, comprising a substrate and a radioactive self-assembled surface layer.
A device which comprises a substrate and a self-assembled layer that has incorporated therein at least one radioactive nuclide, wherein the nuclide is selected from the group consisting of I-131, F-18, C-11, Br-83, Br-82 and Cu-64.
Process according to claim 29, wherein the substrate is made of a material selected from the group consisting of stainless steel and cobalt chrome which have native oxide layers.
29 Process according to claim 17, wherein the self-assembled surface is provided with a radioactive material by in situ covalent attachment of radionuclides.
Dependencies are inferred from the claim text.