Process for the production of nitrogen compounds
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsTakashi Emura, Tsuyoshi Haneishi
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Abstract
A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitrites or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis.
Claims8
A method for preparing isothioureas, guanidines, amidines or amides, which comprises reacting a NH group-containing compound with a compound selected from the group consisting of thiocyanates, cyanamides, nitriles and esters (excluding highly reactive esters) in the presence of a silylating agent.
Dependencies are inferred from the claim text.