Amide compounds and use thereof

An amide compound of the formula

• 195
• wherein
• R1 is hydrogen, alkyl, cycloalkyl, halogen, hydroxyl, alkoxy, haloalkyl, hydroxyalkyl, aralkyl, acyl, alkoxycarbonyl, alkylcarbamoyl, alkylsulfone, nitro, amino optionally having substituents, cyano or phenyl;
• R2 is hydrogen, alkyl, cycloalkyl, phenyl or aralkyl, or a group represented by the formula (II)
• 196
• in the formula (II), R3 is hydrogen, alkyl or amino optionally having substituents, and R4 is hydrogen, alkyl, aralkyl, phenyl, nitro or cyano, or R3 and R4 may be bonded to form a heterocyclic ring containing, in the ring, oxygen atom, sulfur atom or nitrogen atom optionally having a substituent;
• a is an integer of 1 to 4;
• X is CH2, O, S, SO2 or NR7 wherein R7 is hydrogen, alkyl, aralkyl, haloalkyl or acyl;
• and
• Y is a group of the formula (III), (IV), (V) or (VI):
• 197
• in the formulas (III), (IV), (V) and (VI), R5 and R6 are the same or different and each is hydrogen, alkyl, cycloalkyl, phenyl, halogen, hydroxyl, alkoxy, alkoxyalkyl, nitro, amino optionally having substituents or cyano,
• an isomer thereof or a pharmaceutically acceptable salt thereof.