Nucleic acids encoding CD100 molecules

An isolated nucleic acid molecule comprising a nucleotide sequence encoding a protein wherein the protein comprises an amino acid sequence having at least about 80% overall amino acid sequence identity with an amino acid sequence shown in FIG. 2, SEQ ID NO:

• 2.

An isolated nucleic acid molecule encoding an amino acid sequence shown in FIG. 2, SEQ ID NO:

• 2.

An isolated nucleic acid molecule comprising a nucleotide sequence encoding a protein, wherein the protein comprises a semaphorin domain having an amino acid sequence at least 80% identical to an amino acid sequence shown in FIG. 2, SEQ ID NO:

• 2.

An isolated nucleic acid molecule comprising a nucleotide sequence encoding a protein, wherein the protein comprises an extracellular domain having an amino acid sequence at least 80% identical to an amino acid sequence shown in FIG. 2, SEQ ID NO:

• 2.

An isolated nucleic acid molecule encoding a CD100 fusion protein comprising a nucleotide sequence encoding a first peptide having an amino acid sequence at least 80% identical to an amino acid sequence shown in FIG. 2, SEQ ID NO:

• 2 and a nucleic sequence encoding a second peptide corresponding to a moiety that alters the solubility, binding affinity or valency of the first peptide.

An isolated nucleic acid molecule comprising a nucleotide sequence encoding a peptide comprising a fragment of at least about 30 amino acids of the sequence shown in FIG. 2, SEQ ID NO:

• 2.

A vector comprising a nucleotide sequence encoding a CD100 antigen.

A vector comprising a nucleotide sequence encoding a protein comprising an amino acid sequence shown in FIG. 2, SEQ ID NO:

• 2.

An isolated protein having a CD100 activity.

An isolated protein comprising a semaphorin domain having an amino acid sequence at least 80% identical to an amino acid sequence shown in FIG. 2 (SEQ ID NO:

• 2).

An isolated protein comprising an extracellular domain having an amino acid sequence at least 80% identical to an amino acid sequence shown in FIG. 2, SEQ ID NO:

• 2.

An CD100 fusion protein comprising a first peptide having an amino acid sequence at least 80% identical to an amino acid sequence shown in FIG. 2, SEQ ID NO:

• 2 and a second peptide corresponding to a moiety that alters the solubility, binding affinity or valency of the first peptide.

A peptide comprising a fragment of at least about 30 amino acids of the sequence shown in FIG. 2, SEQ ID NO:

• 2.

A vaccine composition comprising at least one antigen and a first agent which stimulates a CD100 ligand-associated signal.

A method for modulating a B cell response comprising contacting the B cell with an agent which modulates a CD100 ligand-associated signal in the B cell, such that a response by the B cell is modulated.

A method for modulating an interaction between an immune cell and a nerve cell in a subject, comprising administering to a subject an agent which modulates a CD100 ligand-associated signal in the nerve cell, such that modulation of the interaction between the immune cell and the nerve cell in the subject occurs.

A method for modulating axonal growth of a neuron, comprising contacting the neuron with a modulating form of CD100, such that axonal growth is modulated.

A method for modulating a T cell response, comprising contacting the T cell with an agent which modulates a CD100 ligand-induced signal in the T cell, such that a response in the T cell is modulated.