Processed human chemokines PHC-1 and PHC-2
OwnerWolf-Georg Forssman, Michel Detheux +3inventors
InventorsWolf-Georg Forssman, Michel Detheux, Marc Parmentier, Ludger Standker, Frank Kirchhoff
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Abstract
The present invention is related to newly identified compounds, polynucleotide sequences encoding the amino acid sequences of the compounds, as well as agonists, antagonists or inhibitors of the compounds for chemokine receptors, especially the CCR-5 receptor and their use in the field of diagnostics and therapeutics involving the chemokine receptors.
Claims26
A compound comprising an amino acid sequence which is at least 60% homologous with SEQ ID NO:
- 1, wherein said compound does not comprise the amino acid sequence SEQ ID NO:
- 3, SEQ ID NO:
- 4 or their biologically active amidated, acetylated, phosphorylated and/or glycosylated derivatives.
A chemokine compound comprising the amino acid sequence SEQ ID NO:
- 1, SEQ ID NO:
- 2 or biologically active fragments or portions thereof.
A chemokine compound comprising the amino acid sequence SEQ ID NO:
- 1, SEQ ID NO:
- 2 or biologically active fragments or portions thereof, modified by or linked to one or more amide, acetyl, phosphoryl and/or glycosyl groups.
A chemokine compound comprising the amino acid sequence of SEQ ID NO:
- 4, wherein at least six amino acids residues, but not more than 15 amino acid residues are deleted from the N-terminal end.
A chemokine compound comprising an amino acid sequence selected from the group consisting of SEQ ID Nos:
- 15, 16, 17, 18, and 19.
Dependencies are inferred from the claim text.