Novel collectins
OwnerNobutaka Wakamiya, Hiroyuki Keshi +3inventors
InventorsNobutaka Wakamiya, Hiroyuki Keshi, Katsuki Ohtani, Takashi Sakamoto, Yuichiro Kishi
Life of this patent
Estimating the term…
Abstract
Provided are isolated collectin (CL-L2s) genes including a base sequence set out in SEQ ID NO: 1, 3, 5, 7, 9, 12, 36, 38 or 40 relating to a novel collectin which are expected to exhibit an antibacterial activity, an antiviral activity and the like particularly in a human body; and isolated collectin proteins including an amino acid sequence set out in SEQ ID NO: 2, 4, 6, 8, 10, 13, 37, 39 or 41 and derivatives and fragments thereof.
Claims40
A protein comprising an amino acid sequence consisting of 271 amino acids set out in the amino acid position 1-271 of SEQ ID NO:
- 2, or a protein consisting of an amino acid sequence set out in SEQ ID NO:
- 2 having deletion, substitution or addition of one or several amino acids therein and having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 1-271 of SEQ ID NO:
- 2, or a derivative or a fragment thereof.
A base sequence set out in SEQ ID NO:
- 45 (corresponding to a base sequence set out in the base position 265-1077 of SEQ ID NO:
- 1), a base sequence encoding an amino acid sequence set out in the amino acid position 1-271 of SEQ ID NO:
- 2 or a fragment thereof, or a base sequence that hybridizes to any one of said base sequences or a base sequence complementary thereto under a stringent condition and encodes a protein having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 1-271 of SEQ ID NO:
- 2.
A protein comprising an amino acid sequence consisting of 245 amino acids set out in the amino acid position 1-245 of SEQ ID NO:
- 4, or a protein consisting of an amino acid sequence set out in the amino acid position 1-245 of SEQ ID NO:
- 4 having deletion, substitution or addition of one or several amino acids therein and having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 1-245 of SEQ ID NO:
- 4, or a derivative or a fragment thereof.
A base sequence set out in SEQ ID NO:
- 46 (corresponding to a base sequence set out in the base position 141-875 of SEQ ID NO:
- 3), a base sequence encoding an amino acid sequence set out in the amino acid position 1-245 of SEQ ID NO:
- 4 or a fragment thereof, or a base sequence that hybridizes to any one of said base sequences or a base sequence complementary thereto under a stringent condition and encodes a protein having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 1-245 of SEQ ID NO:
- 4.
A protein comprising an amino acid sequence consisting of 159 amino acids set out in SEQ ID NO:
- 47 (corresponding to an amino acid sequence set out in the amino acid position 113-271 of SEQ ID NO:
- 2), or a protein consisting of an amino acid sequence set out in SEQ ID NO:
- 2 having deletion, substitution or addition of one or several amino acids therein and having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 113-271 of SEQ ID NO:
- 2, or a derivative or a fragment thereof.
A base sequence set out in SEQ ID NO:
- 48 (corresponding to a base sequence set out in the base position 601-1077 of SEQ ID NO:
- 1), a base sequence encoding an amino acid sequence set out in the amino acid position 113-271 of SEQ ID NO:
- 2 or a fragment thereof, or a base sequence that hybridizes to any one of said base sequences or a base sequence complementary thereto under a stringent condition and encodes a protein having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 113-271 of SEQ ID NO:
- 2.
A protein comprising an amino acid sequence consisting of 197 amino acids set out in the amino acid position 1-197 of SEQ ID NO:
- 6, or a protein consisting of an amino acid sequence set out in the amino acid position 1-197 of SEQ ID NO:
- 6 having deletion, substitution or addition of one or several amino acids therein and having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 1-197 of SEQ ID NO:
- 6, or a derivative or a fragment thereof.
A base sequence set out in SEQ ID NO:
- 55 (corresponding to a base sequence set out in the base position 141-731 of SEQ ID NO:
- 5), a base sequence encoding an amino acid sequence set out in the amino acid position 1-197 of SEQ ID NO:
- 6 or a fragment thereof, or a base sequence that hybridizes to any one of said base sequences or a base sequence complementary thereto under a stringent condition and encodes a protein having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 1-197 of SEQ ID NO:
- 6.
A protein comprising an amino acid sequence consisting of 221 amino acids set out in the amino acid position 1-221 of SEQ ID NO:
- 8, or a protein consisting of an amino acid sequence set out in the amino acid position 1-221 of SEQ ID NO:
- 8 having deletion, substitution or addition of one or several amino acids therein and having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 1-221 of SEQ ID NO:
- 8, or a derivative or a fragment thereof.
A base sequence set out in SEQ ID NO:
- 56 (corresponding to a base sequence set out in the base position 141-803 of SEQ ID NO:
- 7), a base sequence encoding an amino acid sequence set out in the amino acid position 1-221 of SEQ ID NO:
- 8 or a fragment thereof, or a base sequence that hybridizes to any one of said base sequences or a base sequence complementary thereto under a stringent condition and encodes a protein having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 1-221 of SEQ ID NO:
- 8.
A protein comprising an amino acid sequence consisting of 221 amino acids set out in the amino acid position 1-221 of SEQ ID NO:
- 10, or a protein consisting of an amino acid sequence set out in the amino acid position 1-221 of SEQ ID NO:
- 10 having deletion, substitution or addition of one or several amino acids therein and having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 1-221 of SEQ ID NO:
- 10, or a derivative or a fragment thereof.
A base sequence set out in SEQ ID NO:
- 57 (corresponding to a base sequence set out in the base position 141-803 of SEQ ID NO:
- 9), a base sequence encoding an amino acid sequence set out in the amino acid position 1-221 of SEQ ID NO:
- 10 or a fragment thereof, or a base sequence that hybridizes to any one of said base sequences or a base sequence complementary thereto under a stringent condition and encodes a protein having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 1-221 of SEQ ID NO:
- 10.
A protein comprising an amino acid sequence consisting of 271 amino acids set out in the amino acid position 1-271 of SEQ ID NO:
- 13, or a protein consisting of an amino acid sequence set out in the amino acid position 1-271 of SEQ ID NO:
- 13 having deletion, substitution or addition of one or several amino acids therein and having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 1-271 of SEQ ID NO:
- 13, or a derivative or a fragment thereof.
A base sequence set out in SEQ ID NO:
- 58 (corresponding to a base sequence set out in the base position 157-969 of SEQ ID NO:
- 12), a base sequence encoding an amino acid sequence set out in the amino acid position 1-271 of SEQ ID NO:
- 13 or a fragment thereof, or a base sequence that hybridizes to any one of said base sequences or a base sequence complementary thereto under a stringent condition and encodes a protein having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 1-271 of SEQ ID NO:
- 13.
A protein comprising an amino acid sequence consisting of 223 amino acids set out in the amino acid position 1-223 of SEQ ID NO:
- 37, or a protein consisting of an amino acid sequence set out in the amino acid position 1-223 of SEQ ID NO:
- 37 having deletion, substitution or addition of one or several amino acids therein and having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 1-223 of SEQ ID NO:
- 37, or a derivative or a fragment thereof.
A base sequence set out in SEQ ID NO:
- 59 (corresponding to a base sequence set out in the base position 265-933 of SEQ ID NO:
- 36), a base sequence encoding an amino acid sequence set out in the amino acid position 1-223 of SEQ ID NO:
- 37 or a fragment thereof, or a base sequence that hybridizes to any one of said base sequences or a base sequence complementary thereto under a stringent condition and encodes a protein having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 1-223 of SEQ ID NO:
- 37.
A protein comprising an amino acid sequence consisting of 247 amino acids set out in the amino acid position 1-247 of SEQ ID NO:
- 39, or a protein consisting of an amino acid sequence set out in the amino acid position 1-247 of SEQ ID NO:
- 39 having deletion, substitution or addition of one or several amino acids therein and having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 1-247 of SEQ ID NO:
- 39, or a derivative or a fragment thereof.
A base sequence set out in SEQ ID NO:
- 60 (corresponding to a base sequence set out in the base position 265-1005 of SEQ ID NO:
- 38), a base sequence encoding an amino acid sequence set out in the amino acid position 1-247 of SEQ ID NO:
- 39 or a fragment thereof, or a base sequence that hybridizes to any one of said base sequences or a base sequence complementary thereto under a stringent condition and encodes a protein having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 1-247 of SEQ ID NO:
- 39.
A protein comprising an amino acid sequence consisting of 247 amino acids set out in the amino acid position 1-247 of SEQ ID NO:
- 41, or a protein consisting of an amino acid sequence set out in the amino acid position 1-247 of SEQ ID NO:
- 41 having deletion, substitution or addition of one or several amino acids therein and having an equal property to that of the protein having an amino acid sequence set out in the amino acid position 1-247 of SEQ ID NO:
- 41, or a derivative or a fragment thereof.
A base sequence set out in SEQ ID NO:
- 61 (corresponding to a base sequence set out in the base position 265-1005 of SEQ ID NO:
- 40), a base sequence encoding an amino acid sequence set out in the amino acid position 1-247 of SEQ ID NO:
- 41 or a fragment thereof, or a base sequence that hybridizes to any one of said base sequences or a base sequence complementary thereto under a stringent condition and encodes a protein having an equal property to that of the protein having an amino acid sequence set out in amino acid position 1-247 of SEQ ID NO:
- 41.
A transgenic non-human animal having an altered expression level of CL-L2s gene.
A knockout mouse wherein a function of mCL-L2s gene is deficient.
Dependencies are inferred from the claim text.