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US 2003/0158266 A1Published application
2-aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies
AssigneeSigma-Tau Industrie Farmaceutiche Riunite S.p.A.
InventorsNicola Fanto, Gian Piero Moretti, Piero Foresta
Life of this patent
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Abstract
2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopathogenic role of inflammatory cytokines has been ascertained.
Claims7
2-Aminotetralines having formula (I)
- 6
- or their pharmacologically acceptable salts having formula (II)
- 7
- wherein:
- R and R1, are independently, halogen;
- hydroxy;
- C1-C4 alkoxy, optionally substituted in position ω with groups OH, NH2, NR3R4, wherein R3 and R4 are independently H, C1-C4 alkyl, unsubstituted or substituted in position ω with groups OH, NH2;
- C1-C4 alkanoyl;
- C1-C4 alkyl;
- carbamoyl;
- carbamoyloxy;
- amino;
- amino substituted NR3R4, where R3 and R4 have the aforesaid meanings;
- R2 is hydrogen;
- halogen;
- hydroxy;
- methoxy;
- with the proviso that the case is excluded in which the 2-aminotetraline is a raceme in which (a) R═R1═CH3O;
- OH;
- R2═H;
- or (b) R═F R1═CH3O;
- OH;
- R2═H;
- X− is the monovalent anion of a pharmacologically acceptable acid.
21 more elements
An orally or parenterally administrable pharmaceutical composition containing a compound of formula I or II and a pharmaceutically acceptable carrier and/or diluent.
Dependencies are inferred from the claim text.