Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment
OwnerCarl Berthelette, Nicolas Lachance +3inventors
InventorsCarl Berthelette, Nicolas Lachance, Lianhai Li, Claudio Sturino, Zhaoyin Wang
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Abstract
Fluoro substituted cycloalkanoindole derivatives are antagonists of prostaglandins, and as such are useful for the treatment of prostaglandin mediated diseases.
Claims29
A compound of formula I:
- 26
- and pharmaceutically acceptable salts thereof, wherein n is 0 or 1;
- m is 1, 2 or 3;
- R1 is H, C1-C3 alkyl, halogenated C1-C3 alkyl or cyclopropyl;
- R2 is 4-chlorophenyl or 2,4,6-trichlorophenyl.
A compound selected from
- [4-(4-chlorobenzyl)-7-fluoro-5-(methanesulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]-indol-3-yl]acetic acid,
- {4-[1-(4-chlorophenyl)ethyl]-7-fluoro-5-methanesulfonyl-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl}acetic acid,
- [9-(4-chlorobenzyl)-6-fluoro-8-methanesulfonyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl]-acetic acid, and
- [4-(4-chlorobenzyl)-7-fluoro-5-methanesulfonyl-1-oxo-1,2,3,4-tetrahydro-cyclopenta-[b]indol-3-yl]acetic acid, or
- a pharmaceutically acceptable salt thereof.
The compound (3R)-[4-(4-chlorobenzyl)-7-fluoro-5-(methane-sulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid and pharmaceutically acceptable salts thereof.
The compound (±)-4-[1-(4-chlorophenyl)ethyl]-7-fluoro-5-methanesulfonyl-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl}acetic acid and pharmaceutically acceptable salts thereof.
The compound (±)-[9-(4-chlorobenzyl)-6-fluoro-8-methane-sulfonyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl]acetic acid and pharmaceutically acceptable salts thereof.
The compound [4-(4-chlorobenzyl)-7-fluoro-5-methane-sulfonyl-1-oxo-1,2,3,4-tetrahydro-cyclopenta[b]indol-3-yl]acetic acid and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.