Crystals of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione
OwnerTakayuki Oe, Hiroaki Ueno +2inventors
InventorsTakayuki Oe, Hiroaki Ueno, Akira Maruyama, Katsuhiko Masuda
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Abstract
The invention relates to type A crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic absorption peaks (2θ) at 11.5°±0.3°, 14.5°±0.2°, 16.2°±0.3°, 17.0°±0.3°, 17.7°±0.20, 18.6°±0.3°, 19.1°±0.2°, 21.3°±0.4°, 22.4°±0.5°, 25.7°±0.5° and 28.3°±0.5° in a powder X-ray diffraction pattern, and also to a method for preparation thereof, and a pharmaceutical composition comprising the same. The crystal is excellent in stability, and has advantages in handling, storage, and pharmaceutical preparation. The invention also relates to type B, C and D crystals of said compound.
Claims29
Type A crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic absorption peaks (2θ) at 11.5°±0.3° in a powder X-ray diffraction pattern.
Type A crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic absorption peaks (2θ) at 11.5°±0.3° and 25.7°±0.5° in a powder X-ray diffraction pattern.
Type A crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic absorption peaks (2 0) at 22.4°±0.5° and 25.7°±0.5° in a powder X-ray diffraction pattern.
Type A crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic absorption peaks (2 0) at 11.5°±0.3° and 22.4°±0.5° in a powder X-ray diffraction pattern.
Type A crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic absorption peaks (2θ) at 11.5°±0.3°, 17.0°±0.3°, 17.7°±0.2°, 22.4°±0.5° and 25.7°±0.5° in a powder X-ray diffraction pattern.
Type A crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic absorption peaks (2θ) at 11.5°±0.3°, 14.5°±0.2°, 16.2°±0.3°, 17.0°±0.3°, 17.7°±0.2°, 18.6°±0.3°, 19.1°±0.2°, 21.3°±0.4°, 22.4°±0.5°, 25.7°±0.5° and 28.3°±0.5° in a powder x-ray diffraction pattern.
Type B crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic diffraction peaks (2θ) at 10.5°±0.5° in a powder X-ray diffraction pattern.
Type B crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic diffraction peaks (2θ) at 10.5°±0.5° and 20.9°±0.5° in a powder X-ray diffraction pattern.
Type B crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic diffraction peaks (2θ) at 20.9°±0.5° and 23.0°±0.5° in a powder X-ray diffraction pattern.
Type B crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic diffraction peaks (2θ) at 10.5°±0.5° and 23.0°±0.5° in a powder X-ray diffraction pattern.
Type B crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic diffraction peaks (2θ) at 10.5°±0.5°, 20.9°±0.5°, 23.0°±0.5° and 29.2 °±0.5° in a powder X-ray diffraction pattern.
Type B crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic diffraction peaks (2θ) at 10.5°±0.5°, 18.4°±0.5°, 20.9°±0.5°, 23.0°±0.5°, 26.7°±0.5° and 29.2°±0.5° in a powder X-ray diffraction pattern.
Type C crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic diffraction peaks (2θ) at 12.5°±0.5° in a powder X-ray diffraction pattern.
Type C crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic diffraction peaks (2θ) at 12.5°±0.5° and 14.5°±0.5° in a powder X-ray diffraction pattern.
Type C crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic diffraction peaks (2θ) at 14.5°±0.5° and 22.1°±0.5° in a powder X-ray diffraction pattern.
Type C crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic diffraction peaks (2θ) at 12.5°±0.5° and 22.1°±0.5° in a powder X-ray diffraction pattern.
Type C crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic diffraction peaks (2θ) at 12.5°±0.5°, 14.5°±0.5°, 17.6°±0.5° and 22.1°±0.5° in a powder X-ray diffraction pattern.
Type C crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic diffraction peaks (2 0) at 12.5°±0.5°, 14.5°±0.5°, 17.6°±0.5°, 18.8°±0.5°, 22.1°±0.5°, 25.9°±0.5°, 26.6°±0.5° and 28.3°±0.5° in a powder X-ray diffraction pattern.
Type D crystal of 5-[{G-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic diffraction peaks (2θ) at 17.4°±0.2° and 22.2°±0.2° in a powder X-ray diffraction pattern.
Type D crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic diffraction peaks (2 0) at 22.2°±0.2° and 25.3°±0.2° in a powder X-ray diffraction pattern.
Type D crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic diffraction peaks (2θ) at 17.4°±0.2° and 25.3°±0.2° in a powder X-ray diffraction pattern.
Type D crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic diffraction peaks (2θ) at 10.7°±0.2°, 17.4°±0.2°, 22.2°±0.2° and 25.3°±0.2° in a powder X-ray diffraction pattern.
Type D crystal of 5-[{6-(2-fluorobenzyl)oxy-2-naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic diffraction peaks (2θ) at 10.7°±0.2°, 14.5°±0.2°, 15.1°±0.2°, 15.8°±0.2°, 17.4°±0.2°, 18.5°±0.2°, 20.5°±0.2°, 22.2°±0.2°, 25.3°±0.2°, 26.8°±0.2° and 27.8°±0.2° in a powder X-ray diffraction pattern.
Dependencies are inferred from the claim text.