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US 2003/0158226 A1Published application
Alkyl urea retinoid agonists
AssigneeRoche Bioscience, a division of Syntex (U.S.A.) LLC
InventorsPaula Nanette Belloni, Denis John Kertesz, Michael Klaus, Jean-Marc Lapierre
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Abstract
The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders and methods for delivering formulations into the lung of a mammal suffering from emphysema, cancer and dermatological disorders.
Claims24
A compound according to structural formula (I):
- 23
- or a salt, solvate or hydrate thereof wherein:
- n is an integer from 0 to 2;
- X is S, O or NR3R4;
- R3 and R4 are independently hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl, or together with the nitrogen atom to which they are attached form a heterocyclyl ring;
- Y is —OR5, —SR5 or —NR6R7;
- R5 is hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl;
- R6 and R7 are independently hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl or together with the nitrogen atom to which they are attached form a heterocyclyl ring;
- R1 is (C2-C8) alkyl;
- R2 is hydrogen, alkyl, hydroxy or oxo;
- and
- R9 is hydrogen, alkyl, haloalkyl, halo, cyano, nitro or alkoxy.
9 more elements
Dependencies are inferred from the claim text.