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AssigneeSmithKline Beecham Corporation
InventorsChristopher Norbert Johnson, Geoffrey Stemp
Estimating the term…
Oompounds of formula (I), wherein R2 represents a hydrogen atom or a C1-4 alkyl group; q is 1 or 2; A represents a group of formula (a), (b), (c) or (d), wherein Ar represents an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring; or an optionally substituted bicyclic ring system; Ar1 and Ar2 each independently represent an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring; and Y represents a bond, —NHCO—, —CONH—, —CH2—, or —(CH2)mY1(CH2)n—, wherein Y1 represents O, S, SO2 or CO and m and n each represent zero or (I) such that the sum of m+n is zero or 1; providing that when A represents a group of formula (a), any substituent present in Ar ortho to the carboxamide moiety is necessarily a hydrogen or methoxy group; r and s independently represent an integer from zero to 3 such that the sum of r and s is equal to an integer from 1 to 4; V represents a bond, O or S; and salts thereof. Compounds of formula (I) and their salts have affinity for dopamine receptors, in particular the D3 receptor, and thus potential in the treatment of conditions wherein modulation of the D3 receptor is beneficial, e.g. as antipsychotic agents.
A compound of formula (I):
A compound according to any of the preceding claims wherein rings Ar, Ar1, or Ar2 are each independently optionally substituted by one or more substituents selected from:
A compound of formula (I) which is:
A process for preparing compounds of formula (I) which process comprises:
Dependencies are inferred from the claim text.