Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
OwnerJoseph F. Foss, Michael F. Roizen +3inventors
InventorsJoseph F. Foss, Michael F. Roizen, Jonathan Moss, Chun-Su Yuan, William Drell
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Abstract
A method of preventing or treating an opioid-induced side effect in a patient who has been chronically taking opioids, the method comprising administering a quaternary derivative of noroxymorphone in an amount sufficient to prevent or treat the side effect in the patient, but which amount would be insufficient to treat a patient with the same opioid-induced side effect who had not chronically been administered opioids.
Claims25
A method of preventing or treating an opioid-induced side effect in a patient chronically administered opioids, the method comprising administering a quaternary derivative of noroxymorphone in an amount sufficient to prevent or treat the side effect in the patient, but which would be insufficient to treat a patient with the same opioid-induced side effect who had not chronically been administered opioids.
A method of preventing or treating opioid-induced constipation, the method comprising:
- determining how long the patient has been administered opioids;
- selecting a dose of a quaternary derivative of noroxymorphone based on the length of time the patient has been administered opioids, wherein the dose selected for a patient chronically administered opioids is at least 10% lower than the dose selected for a patient not chronically administered opioids;
- and
- administering the selected dose of the quaternary derivative of noroxymorphone to the patient.
Dependencies are inferred from the claim text.