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US 2003/0158216 A1Published application
2-acyl indole derivatives and their use as antitumor agents
AssigneeBaxter Oncology GmbH
InventorsThomas Beckers, Silke Bassner, Thomas Klenner, Siavosh Mahboobi, Herwig Pongratz, Markus Frieser, Harald Hufsky, Jorg Hockemeyer, Heinz-Herbert Fiebig, Angelika Burger, Frank-D. Bohmer
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Abstract
The invention relates to novel indole and heteroindole derivatives of the formula I 1 to their tautomers, their stereoisomers, their mixtures and their salts, to their preparation and to the use of indole derivatives of the formula I as antitumor agents.
Claims15
Use of at least one compound of the formula I
- 31
- in which
- R1 is hydrogen, (C1-C6)-alkylcarbonyl, preferably acetyl, (C1-C6)-alkyl, mono-(C1-C6)-alkylamino-(C1-C4)-alkyl, di-(C1-C6)-alkylamino-(C1-C4)-alkyl, where the two (C1-C6)-alkyl radicals together may form a ring, which optionally contains one or more NH, N-(C1-C6)-alkyl, O or S members, (C6-C14)-aryl-(C1-C6)-alkyl or (C6-C14)-aryl-(C1-C6)-alkoxy-(C1-C6)-alkyl;
- R2 is a hydrogen atom, halogen, cyano, nitro, (C1-C6)-alkyl, (C1-C6)-alkyl which is substituted by one or more halogen atoms, preferably trifluoromethyl, (C1-C6)-alkoxy which is substituted by one or more halogen atoms, preferably trifluoromethoxy, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C3-C8)-cycloalkyl, (C1-C6)-alkoxy, (C1-C6)-alkoxycarbonyloxy, (C1-C6)-alkylcarbonyloxy, (C1-C4)-alkylthio, (C1-C4)-alkylsulfinyl, (C1-C4)-alkylsulfonyl, (C1-C6)-alkoxy-(C1-C6)-alkyl, amino, mono-(C1-C6)-alkylamino, di-N,N-(C1-C6)-alkylamino, where the two (C1-C6)-alkyl radicals together may form a ring, which optionally contains one or more NH, N-(C1-C6)-alkyl, O or S, (C6-C14)-aryl, (C6-C14)-aryloxy, (C6-C14)-aryl-(C1-C4)-alkyl, (C6-C14)-aryl-(C1-C4)-alkoxy-(C1-C4)-alkyl, (C1-C6)-alkylcarbonyl, (C1-C6)-alkoxycarbonyl or hydroxyl;
- A, B, C and D independently of one another are a nitrogen atom (in which case R3, R4, R5 and R6 represent the free electron pair at the nitrogen atom) or are a carbon atom substituted by one of the radicals R3-R6;
- R3, R4, R5 and R6 independently of one another are, when attached to nitrogen, a free electron pair, or, when attached to carbon, hydrogen, halogen, cyano, nitro, straight-chain or branched (C1-C6)-alkyl, straight-chain or branched (C1-C6)-alkyl which is substituted by one or more halogen atoms, preferably trifluoromethyl, straight-chain or branched (C1-C6)-alkoxy which is substituted by one or more halogen atoms, preferably trifluoromethoxy, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C3-C8)-cycloalkyl, straight-chain or branched (C1-C6)-alkoxy, preferably methoxy, straight-chain or branched (C1-C6)-alkylenedioxy, preferably methylenedioxy, (C1-C6)-alkoxycarbonyloxy, (C1-C6)-alkylcarbonyloxy, (C1-C4)-alkylthio, (C1-C4)-alkylsulfinyl, (C1-C4)-alkylsulfonyl, carboxyl, (C1-C6)-alkyl carboxylate, carboxamide, N-(C1-C4)-alkyl-carboxamide, N,N-di-(C1-C4)-alkyl-carboxamide, (C1-C6)-alkoxy-(C1-C6)-alkyl, amino, mono-(C1-C6)-alkylamino, N,N-di-(C1-C6)-alkyl-amino, where the two C1-C6-alkyl radicals together may form a ring, which optionally contains one or more NH, N-(C1-C6)-alkyl, O or S, (C6-C14)-aryl, (C6-C14)-aryloxy, (C6-C14)-aryl-(C1-C4)-alkyl, (C6-C14)-aryl-(C1-C4)-alkoxy-(C1-C4)-alkyl, (C1-C6)-alkylcarbonyl, (C1-C6)-alkylcarbonyloxy, (C1-C6)-alkoxycarbonyl, hydroxyl, where two directly adjacent radicals may be attached to one another;
- Y is unsubstituted (C6-C14)-aryl or (C6-C14)-aryl which is fully or partially substituted by identical or different substituents, preferably phenyl or 1- or 2-naphthyl, or is unsubstituted (C1-C13)-heteroaryl or (C1-C13)-heteroaryl which is fully or partially substituted by identical or different substituents and has in each case at least one to four N, NH, N-(C1-C6)-alkyl, O and/or S as ring members, or is unsubstituted (C3-C8)-cycloalkyl or (C3-C8)-cycloalkyl which is fully or partially substituted by identical or different substituents, where the identical or different substituents are selected independently of one another from the group consisting of halogen, preferably fluorine, chlorine, bromine or iodine;
- cyano;
- straight-chain or branched cyano-(C1-C6)-alkyl;
- hydroxyl;
- straight-chain or branched (C1-C6)-alkyl which is substituted by one or more hydroxyl groups;
- carboxyl;
- (C1-C6)-alkyl carboxylate, carboxamide;
- N-(C1-C6)-alkyl-carboxamide, N,N-di-(C1-C4)-alkyl-carboxamide, nitro, straight-chain or branched (C1-C6)-alkyl, straight-chain or branched (C1-C6)-alkyl which is substituted by one or more halogen atoms, preferably trifluoromethyl, straight-chain or branched (C1-C6)-alkoxy which is substituted by one or more halogen atoms, preferably trifluoromethoxy, straight-chain or branched (C2-C6)-alkenyl, straight-chain or branched (C2-C6)-alkynyl, (C3-C8)-cycloalkyl, straight-chain or branched (C1-C6)-alkoxy, preferably methoxy, straight-chain or branched (C1-C6)-alkylenedioxy, preferably methylenedioxy, thio (—SH), straight-chain or branched (C1-C6)-alkylthio, (C1-C6)-alkylsulfinyl, (C1-C6)-alkylsulfonyl, (C1-C6)-alkoxy-(C1-C6)-alkyl, amino, straight-chain or branched mono-(C1-C6)-alkylamino, straight-chain or branched N,N-di-(C1-C6)-alkylamino, where the two (C1-C6)-alkyl radicals together may form a ring, which may optionally contain one or more NH, N-(C1-C6)-alkyl, O and/or S, (C6-C14)-aryl, (C6-C14)-aryloxy, (C6-C14)-aryl-(C1-C6)-alkyl, (C6-C14)-aryl-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-alkylcarbonyl, (C1-C6)-alkylcarbonyloxy, (C1-C6)-alkoxycarbonyl, (C1-C6)-alkoxycarbonyloxy, straight-chain or branched mono- and N,N-di-(C1-C6)-alkylcarbonylamino, straight-chain or branched mono- and N,N-di-(C1-C6)-alkoxycarbonylamino, straight-chain or branched N-(C1-C6)-alkylcarbonyl-N-(C1-C6)-alkylamino, straight-chain or branched N-(C1-C6)-alkoxycarbonyl-N-(C1-C6)-alkylamino, formylamino, formyl, where two directly adjacent radicals may be attached to one another;
- X is an oxygen or sulfur atom, is NH, or is a generally (at the same C atom) substituted hydroxyl and hydrogen (—CH(OH)—);
- its stereoisomers, its tautomers, mixtures thereof and the pharmaceutically acceptable salts thereof, for preparing a medicament for the treatment of oncoses in mammals.
13 more elements
Use of at least one compound of the formula I according to any of the preceding claims, characterized in that R1, R2, R3, R5, R6, A, B, C, D, X and Y are as defined above, with the proviso that the radical R4 is methoxy.
Use of at least one compound of the formula I according to any of the preceding claims, characterized in that R1-R6, A, B, C, D and X are as defined above, with the proviso that, the radical Y is substituted or unsubstituted (C6-C14)-aryl or (C1-C13)-heteroaryl which contains at least one to four N, NH, O and/or S as ring members.
Use of at least one compound of the formula I according to any of the preceding claims, characterized in that R1-R6, A, B, C, D and X are as defined above, with the proviso that the radical Y is (C6-C14)-aryl or (C1-C13)-heteroaryl which contains at least one N, NH, O and/or S as ring members, which is substituted by at least one radical selected from the group consisting of hydrogen, amino, halogen, nitro, cyano, straight-chain or branched (C1-C6)-alkoxy, preferably methoxy;
- straight-chain or branched (C1-C6)-alkyl, preferably methyl;
- hydroxyl;
- (C1-C6)-alkylcarbonyloxy, (C1-C6)-alkoxycarbonyloxy;
- straight-chain or branched (C1-C6)-alkoxy which is substituted by one or more halogen atoms, preferably trifluoromethoxy;
- straight-chain or branched (C1-C6)-alkyl which is substituted by one or more halogen atoms, preferably trifluoromethyl.
2 more elements
Use of at least one compound of the formula I according to any of the preceding claims, characterized in that R1-R6, A, B, C, D and X are as defined above, characterized in that the radical Y is a 1-phenyl radical which is unsubstituted or substituted by hydrogen, 3,4-dichloro, 2- or 3-methoxy, 2,4-dimethoxy, 3-nitro[lacuna]3-trifluoromethyl, 2,3,4-trimethoxy, 3,4,5-trimethoxy.
Compounds of the formula I
- 32
- in which
- R1 is hydrogen, (C1-C6)-alkylcarbonyl, preferably acetyl, (C1-C6)-alkyl, mono-(C1-C6)-alkylamino-(C1-C4)-alkyl, di(C1-C6)-amino-(C1-C4)-alkyl, where the two (C1-C4)-alkyl radicals together may form a ring, which optionally contains one or more NH, N-(C1-C[lacuna])-alkyl, O or S members, (C6-C14)-aryl-(C1-C6)-alkyl or (C6-C14)-aryl-(C1-C6)-alkoxy-(C1-C6)-alkyl;
- R2 is a hydrogen atom, halogen, cyano, nitro, (C1-C6)-alkyl, (C1-C6)-alkyl which is substituted by one or more halogen atoms, preferably trifluoromethyl, (C1-C6)-alkoxy which is substituted by one or more halogen atoms, preferably trifluoromethoxy, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C3-C8)-cycloalkyl, (C1-C[lacuna])-alkoxy, (C1-C[lacuna])-alkoxycarbonyloxy, (C1-C[lacuna])-alkylcarbonyloxy, (C1-C)-alkylthio, (C1-C4)-alkylsulfinyl, (C1-C4)-alkylsulfonyl, (C1-C4)-alkoxy-(C1-C4)-alkyl, amino, mono-(C1-C[lacuna])-alkylamino, di-(C1-C[lacuna])-alkyl)-amino, where the two C1-C4-alkyl radicals together may form a ring, which optionally contains one or more NH, N-(C1-C4)alkyl, O or S, (C6-C14)-aryl, (C6-C14)-aryloxy, (C6-C14)-aryl-(C1-C4)-alkyl, (C6-C14)-aryl-(C1-C4)-alkoxy-(C1-C4)-alkyl, (C1-C6)-alkyl-carbonyl, (C1-C6)-alkoxycarbonyl or hydroxyl;
- A, B, C and D independently of one another are a nitrogen atom (in which case R3, R4, R5 and R6 represent the free electron pair at the nitrogen atom) or are a carbon atom substituted by one of the radicals R3-R6;
- R3, R4, R5 and R6 independently of one another are, when attached to nitrogen, a free electron pair, or, when attached to carbon, hydrogen, halogen, cyano, nitro, straight-chain or branched (C1-C6)-alkyl, straight-chain or branched (C1-C6)-alkyl which is substituted by one or more halogen atoms, preferably trifluoromethyl, straight-chain or branched (C1-C6)-alkoxy which is substituted by one or more halogen atoms, preferably trifluoromethoxy, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C3-C8)-cycloalkyl, straight-chain or branched (C1-C6)-alkoxy, straight-chain or branched (C1-C6)-alkylenedioxy, (C1-C6)-alkoxy-carbonyloxy, (C1-C6)-alkylcarbonyloxy, (C1-C[lacuna])-alkylthio, (C1-C4)-alkylsulfinyl, (C1-C4)-alkylsulfonyl, carboxyl, (C1-C6)-alkyl carboxylate, carboxamide, N-(C1-C4)-alkyl-carboxamide, N,N-di-(C1-C4)-alkyl-carboxamide, (C1-C6)-alkoxy-(C1-C6)-alkyl, amino, mono-(C1-C6)-alkylamino, di-(C1-C6)-alkyl)-amino, where the two C1-C4-alkyl radicals together may form a ring, which optionally contains one or more NH, N-(C1-C4)-alkyl, O or S, aryl, aryloxy, aryl-(C1-C4)-alkyl, aryl-(C1-C4)-alkoxy-(C1-C4)-alkyl, (C1-C6)-alkylcarbonyl, (C1-C6)-alkoxycarbonyl, hydroxyl, where two directly adjacent radicals may be attached to one another;
- Y is unsubstituted (C10-C14)-aryl or (C10-C14)-aryl which is fully or partially substituted by identical or different substituents, preferably 1- or 2-naphthyl, or is unsubstituted (C1-C13)-heteroaryl or (C1-C13)-heteroaryl which is fully or partially substituted by identical or different substituents and has in each case at least one to four N, NH, N-(C1-C6)-alkyl, O and/or S as ring members, or is unsubstituted (C3-C8)-cycloalkyl or (C3-C8)-cycloalkyl which is fully or partially substituted by identical or different substituents, where the identical or different substituents are selected independently of one another from the group consisting of halogen, preferably fluorine, chlorine, bromine or iodine;
- cyano;
- straight-chain or branched cyano-(C1-C6)-alkyl;
- hydroxyl;
- straight-chain or branched (C1-C6)-alkyl which is substituted by one or more hydroxyl substituents;
- carboxyl;
- (C1-C6)-alkyl carboxylate;
- carboxamide;
- N-(C1-C6)-alkyl-carboxamide, N,N-di-(C1-C4)-alkyl-carboxamide, nitro, straight-chain or branched (C1-C6)-alkyl, straight-chain or branched (C1-C6)-alkyl which is substituted by one or more halogen atoms, preferably trifluoromethyl, straight-chain or branched (C1-C6)-alkoxy which is substituted by one or more halogen atoms, preferably trifluoromethoxy, straight-chain or branched (C2-C6)-alkenyl, straight-chain or branched (C2-C6)-alkynyl, (C3-C8)-cycloalkyl, straight-chain or branched (C1-C6)-alkoxy, preferably methoxy, straight-chain or branched (C1-C6)-alkylenedioxy, preferably methylenedioxy, thio (—SH), straight-chain or branched (C1-C6)-alkylthio, (C1-C6)-alkylsulfinyl, (C1-C6)-alkylsulfonyl, (C1-C6)-alkoxy-(C1-C6)-alkyl, amino, straight-chain or branched mono-(C1-C6)-alkylamino, straight-chain or branched N,N-di-(C1-C6)-alkylamino, where the two (C1-C6)-alkyl radicals together may form a ring, which may optionally contain one or more NH, N-(C1-C6)-alkyl, O and/or S, (C6-C14)-aryl, (C6-C14)-aryloxy, (C6-C14)-aryl-(C1-C6)-alkyl, (C6-C14)-aryl-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-alkylcarbonyl, (C1-C6)-alkylcarbonyloxy, (C1-C6)-alkoxycarbonyl, (C1-C6)-alkoxycarbonyloxy, straight-chain or branched mono- and N,N-di-(C1-C6)-alkylcarbonylamino, straight-chain or branched mono-N- and N,N-di-(C1-C6)-alkoxycarbonylamino, straight-chain or branched N-(C1-C6)-alkylcarbonyl-N-(C1-C6)-alkylamino, straight-chain or branched N-(C1-C6)-alkoxycarbonyl-N-(C1-C6)-alkylamino, formylamino, formyl, where two directly adjacent radicals may be attached to one another;
- X is an oxygen or sulfur atom, is NH, or is a generally (at the same C atom) substituted hydroxyl and hydrogen (—CH(OH)—);
- their stereoisomers, their tautomers, and the pharmaceutically acceptable salts thereof, except for the racemic compounds according to formula I where R1=R2=R3=R5=R6=hydrogen, X=oxygen or, if R4=H, generally substituted hyroxyl and hydrogen, Y=3-carboxypyridin-4-yl and R4=hydrogen or methoxy, and the compounds 2-cyclopropylcarbonylindole and 2-cyclohexyl-carbonylindole.
14 more elements
Compounds of the formula I according to claim 11
- 33
- in which A, B, C, D, X, Y and R1 to R6 are as defined in claim 13 [sic], including the compounds of the formula I where R1=R2=R3=R5=R6=hydrogen, X=oxygen or, if R4=H, generally substituted hydroxyl and hydrogen, Y×3-carboxypyridin-4-yl and R4=hydrogen or methoxy, and the compounds 2-cyclopropyl-carbonylindole and 2-cyclohexylcarbonylindole for use as medicaments, in particular as antitumor agents.
Dependencies are inferred from the claim text.