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OwnerBruce A. Freeman, Margaret Tarpey +3inventors
InventorsBruce A. Freeman, Margaret Tarpey, Tom Ryan, Tim Townes, Mutay Aslan
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Disclosed is a method for alleviating the oxidative impairment of vascular function by inhibiting the activity of xanthine oxidase, or active forms thereof. Xanthine oxidase levels have been shown to be increased by a variety of conditions, including sickle cell disease. In the present disclosure, allopurinol is used to inhibit xanthine oxidase activity. As a result of the inhibition of xanthine oxidase, .NO levels in a subject can be maintained. In addition to sickle cell disease, allopurinol inhibition of xanthine oxidase may be used to treat other conditions, including, but not limited to, respiratory distress, kidney disease, liver disease, ischemia-reperfusion injury, organ transplant, sepsis, burns, viral infections and hemorrhagic shock.
A method of treating an inflammatory condition in a subject in need of such treatment comprising administering to the subject an effective amount of allopurinol, or a pharmaceutically acceptable salt thereof, under conditions such that said treatment is effected.
A pharmaceutical composition for the treatment of sickle cell disease comprising allopurinol, or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable carrier thereof.
A pharmaceutical composition for the treatment of sickle cell disease comprising oxypurinol, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier thereof.
A method of maintaining a biological function of .NO, or active forms thereof, in a subject comprising administering to the subject an effective amount of allopurinol, or a pharmaceutically acceptable salt thereof, to effect said maintenance.
A method of protecting a subject from oxidative stress comprising administering to the subject an effective amount of allopurinol, or a pharmaceutically acceptable salt thereof, to effect said protection.
A method of restoring vascular function in a subject suffering from sickle cell disease comprising administering to the subject an effective amount of allopurinol, or a pharmaceutically acceptable salt thereof, to effect said restoration.
Dependencies are inferred from the claim text.