Modulators of phosphoinositide 3-kinase

A method for modulating the activity of a PI3 kinase, comprising:

• contacting said PI3 kinase with an effective amount of a compound of formula
• 11
• wherein X is CR9R10, O, NR11 (where R9 and R10 are each independently H, lower alkyl, lower alkoxy, or halo, and R11 is H or lower alkyl);
• or single bond
• R1 is H, lower alkyl, aryl, or aralkyl;
• R2 is H, lower alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, lower alkoxy, amino, lower alkylamino, lower acylamino, arylamino, arylacyl-amino, heteroaryl-amino, heteroaryl-acyl amino, thio, lower alkylthio, arylthio, or aralkyl-thio, where aryl and heteroaryl are substituted with 0-3 substituents selected from the group consisting of halo, trihalomethyl, hydroxy, lower alkyl and lower alkoxy;
• R3, R4, R5, R6, R7, and R8 are each independently H, lower alkyl, lower alkoxy, or halo;
• or a pharmaceutically acceptable salt or ester thereof.

A composition for modulating the activity of a PI3 kinase, said composition comprising:

• a therapeutic amount of a compound of formula 1
• 12
• wherein X is CR9R10, O, NR11 (where R9 and R10 are each independently H, lower alkyl, lower alkoxy, or halo, and R11 is H or lower alkyl), or single bond;
• R1 is H, lower alkyl, aryl, or aralkyl;
• R2 is H, lower alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, lower alkoxy, amino, lower alkylamino, lower acylamino, arylamino, arylacyl-amino, heteroaryl-amino, heteroaryl-acyl amino, thio, lower alkylthio, arylthio, or aralkyl-thio, where aryl and heteroaryl are substituted with 0-3 substituents selected from the group consisting of halo, trihalomethyl, hydroxy, lower alkyl and lower alkoxy;
• R3, R4, R5, R6, R7, and R8 are each independently H, lower alkyl, lower alkoxy, or halo;
• or a pharmaceutically acceptable salt or ester thereof;
• and a pharmaceutically acceptable excipient.