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US 2003/0158210 A1Published application
Amino acid ester containing azole antifungals
AssigneeJanssen Pharmaceutica NV
InventorsLieven Meerpoel, Jan Heeres, Robert Jozef Maria Hendrickx
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Abstract
The present invention concerns novel compounds of formula 1 the N-oxide forms, the pharmaceutically acceptable addition salts thereof and stereochemically isomeric forms thereof, wherein —A—B— forms a bivalent radical of formula —N═CH— (a), —CH═N— (b), —CH═CH— (c), L represents the acyl moiety of an amino acid; D is an azole containing 1,3- or 1,4-dioxolane derivative as broad-spectrum antifungals; their preparation, compositions containing them and their use as a medicine.
Claims19
A compound of formula (I),
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- a N-oxide form, a pharmaceutically acceptable addition salt or a stereochemically isomeric form thereof, wherein
- —A—B— forms a bivalent radical of formula:
- —N═CH— (a),—CH═N— (b),—CH═CH— (c),
- wherein one hydrogen atom in the radicals (a) and (b) may be replaced with a C1-6-alkyl-radical and up to two hydrogen atoms in radical (c) may be replaced by a C1-6-alkyl-radical;
- L represents the acyl moiety of an amino acid;
- D is a radical of formula
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- wherein
- X is N or CH;
- R1 is halo;
- R2 is hydrogen or halo.
9 more elements
Dependencies are inferred from the claim text.