Ligands of melanocortin receptors and compositions and methods related thereto

A compound having the following structure:

• 200
• or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof,
• wherein:
• n is 0, 1, 2, or 3;
• m is 1, 2, 3, or 4;
• A is alkanediyl optionally substituted with R7;
• R1 and R2 are the same or different and independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl, or substituted heterocyclealkyl, or —C(═O)R10;
• or R1 and R2 taken together with the nitrogen atom to which they are attached form heterocycle or substituted heterocycle;
• R3a and R3b are the same or different and independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl, or substituted heterocyclealkyl;
• or R3a and R3b taken together with the carbon atom to which they are attached form a homocycle, substituted homocycle, heterocycle, or substituted heterocycle;
• or R3a and the carbon atom to which it is attached taken together with one or both of R1 and R2 and the nitrogen to which it is attached form heterocycle or substituted heterocycle;
• R4 is aryl, substituted aryl, heteroaryl, or substituted heteroaryl;
• R5 is hydrogen, hydroxy, alkyl, substituted alkyl, aryl, substituted aryl, heterocycle, or substituted heterocycle;
• R6 is cyano, nitro, heterocycle, substituted heterocycle, —NR8R9, —C(═O)NR8R9, —C(═O)OR8, —OC(═O)OR8, —OC(═O)R8, —OC(═O)NR8R9, —NR8C(═O)OR8, —NR8C(═O)R10, —NR8C(═O)NR8R9, —NR8S(═O)pR1, —S(═O)pR1, —S(═O)pNR8R9, —NR8S(═O)pNR8R9, or —OR12;
• R7 is alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl, substituted heterocyclealkyl, cyano, nitro, —NR8R9, —C(═O)NR8R9, —C(═O)OR8, —NR8C(═O)R10, —NR8C(═O)NR8R9, —NR8S(═O)pR11, —S(═O)pR11, —NR8S(═O)pNR8R9, or —OR12;
• R8 and R9 are the same or different and, at each occurrence, independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl, or substituted heterocyclealkyl;
• R10, R11, and R12 are the same or different and, at each occurrence, independently hydrogen, halogen, cyano, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl or substituted heterocyclealkyl;
• W1, W2, W3, W4, Y1, Y2, Y3 and Y4 are the same or different and, at each occurrence, independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl, substituted heterocyclealkyl, cyano, nitro, —NR8R9, —C(═O)NR8R9, —C(═O)OR10, —NR8C(═O)R10, —NR8C(═O)NR8R9, —NR8S(═O)pR11, —S(═O)pR11, —NR8S(═O)pNR8R9, or —OR12;
• or any of one of W1, W2, W3 or W4 and the carbon to which it is attached together with any one of Y1, Y2, Y3 or Y4 and the carbon to which it is attached form a bridging heterocycle or substituted heterocycle;
• and
• p is, at each occurrence, 0, 1 or 2.