Novel compounds for inhibition of Tie-2

A compound of formula I

• 39
• wherein V is H or
• 40
• R1 can be independently H, alkyl, alkenyl, cycloalkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, alkylaryl, N—R6R7, N—(CO)R6R7, N—R6(CO)R7 or N—(CO)—O—R6R7,
• R8 can be independently H, alkyl, alkenyl, cycloalkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, alkylaryl, N—R3R4, N—(CO)R3R4, N—R3(CO)R4, N—(CO)—O—R3R4, O—R3, CO—R3, CO—OR3 or O—CO—R3,
• R2, R5, can be independently H, alkyl, alkenyl, cycloalkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, alkylaryl, Br, Cl, F, CF3,
• R3, R4, R6, R7 can be independently H, alkyl, alkenyl, cycloalkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, alkylaryl, COOR5 and CO—R5, and may for a ring structure,
• X, Y, Z can be independently CH or N, and
• U can be independently S or NH,
• W can be independently NH, O or S, and
• racemic-diastereomeric mixtures, optical isomers, and pharmaceutically acceptable salts thereof.