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US 2003/0158193 A1Published application
Alkylated imidazopyridine derivatives
AssigneeAltana Pharma AG
InventorsJ?ouml;rg Senn-Bilfinger, Wilm Buhr
Life of this patent
Estimating the term…
Abstract
Compounds of the formula 1 1 in which the substituents have the meanings mentioned in the description are suitable for the prevention and treatment of gastrointestinal diseases.
Claims9
A compound of the formula 1
- 9
- in which
- R1 is hydrogen, 1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl or hydroxy-1-4C-alkyl,
- R2 is hydrogen, 1-4C-alkyl, hydroxy-1-4C-alkyl, halogen, 2-4C-alkenyl or 2-4C-alkynyl,
- R3 is hydrogen, halogen, trifluoromethyl, 1-4C-alkyl, 2-4C-alkenyl, 2-4C-alkynyl, carboxyl, —CO-1-4C-alkoxy, hydroxy-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, fluoro-1-4C-alkoxy-1-4C-alkyl or the radical —CO—NR3aR3b,
- one of the substituents R4a and R4b is hydrogen, 1-7C-alkyl, 2-7C-alkenyl, phenyl or phen-1-4C-alkyl and the other is hydroxyl, 1-4C-alkoxy, 1-4C-alkoxy-1-4C-alkoxy, 1-4C-alkylcarbonyloxy or the radical R4′, or in which R4a and R4b together are O (oxygen) or 1-7C-alkylidene,
- where R4′ is a radical from which a hydroxyl group is formed under physiological conditions,
- one of the substituents R5a and R5b is hydrogen, 1-7C-alkyl, 2-7C-alkenyl, phenyl or phen-1-4C-alkyl and the other is hydrogen, hydroxyl, 1-4C-alkoxy, 1-4C-alkoxy-1-4C-alkoxy, 1-4C-alkylcarbonyloxy or the radical R5′, or in which R5a and R5b together are O (oxygen) or 1-7C-alkylidene,
- where R5′ is a radical from which a hydroxyl group is formed under physiological conditions,
- or in which
- one of the substituents R4a and R4b on the one hand and one of the substituents R5a and R5b on the other hand is in each case hydrogen, 1-7C-alkyl, 2-7C-alkenyl, phenyl or phen-1-4C-alkyl, and the other substituents in each case together form a 1-4C-alkylenedioxy radical,
- where at least one of the substituents R4a, R4b, R5a and R5b must have the meaning 1-7C-alkyl, 1-7C-alkenyl, phenyl or phen-1-4C-alkyl or where either R4a and R4b or R5a and R5b together must be 1-7C-alkylidene,
- R6 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonylamino, 1-4C-alkoxy-1-4C-alkoxycarbonylamino or trifluoromethyl,
- R7 is hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy and
- X is O (oxygen) or NH,
- where
- R3a is hydrogen, 1-7C-alkyl, hydroxy-1-4C-alkyl or 1-4C-alkoxy-1-4C-alkyl and
- R3b is hydrogen, 1-7C-alkyl, hydroxy-1-4C-alkyl or 1-4C-alkoxy-1-4C-alkyl,
- or where
- R3a and R3b together, including the nitrogen atom to which both are bonded, are a pyrrolidino, piperidino or morpholino radical,
- or its salts.
18 more elements
Dependencies are inferred from the claim text.