Genetic polymorphisms in the preprotachy kinin gene

An isolated nucleic acid molecule selected from the group of:

• the nucleic acid sequence of FIG. 2 with T at position 33612 as defined by the position in FIG. 2;
• the nucleic acid sequence of FIG. 2 with C at position 33949 as defined by the position in FIG. 2;
• the nucleic acid sequence of FIG. 2 with T at position 37025 as defined by the position in FIG. 2;
• the nucleic acid sequence of FIG. 2 with A at position 37114 as defined by the position in FIG. 2;
• the nucleic acid sequence of FIG. 2 with C at position 37434 as defined by the position in FIG. 2;
• the nucleic acid sequence of FIG. 2 with G at position 41112 as defined by the position in FIG. 2;
• the nucleic acid sequence of FIG. 2 with G at position 41172 as defined by the position in FIG. 2;
• or
• a complementary strand thereof or a fragment thereof of at least 20 bases comprising at least one of the single nucleotide polymorphisms.

An oligonucleotide probe for detecting a polymorphism in the NKNA gene capable of hybridizing specifically to a nucleic acid wherein the nucleotide polymorphism in the NKNA gene is selected from at least one of

• a C or a T at position 33612 in FIG. 2,
• a T or a C at position 33949 in FIG. 2,
• a C or a T at position 37025 in FIG. 2,
• a G or an A at position 37114 in FIG. 2,
• an A or a C at position 37434 in FIG. 2,
• a T or a G at position 41112 in FIG. 2, and
• a G or an A at position 41172 in FIG. 2, and combinations thereof as well as their reverse complement.

A diagnostic kit comprising at least one of an allele-specific nucleic acid primer capable of detecting a polymorphism in the NKNA gene at one or more of the positions 33612, 33949, 37025, 37114, 37434, 41112 and 41172 of the nucleotide sequence in FIG. 2 and an oligonucleotide probe for detecting a polymorphism in the NKNA gene capable of hybridizing specifically to a nucleic acid wherein the nucleotide polymorphism in the NKNA gene is selected from at least one of

• a C or a T at position 33612 in FIG. 2,
• a T or a C at position 33949 in FIG. 2,
• a C or a T at position 37025 in FIG. 2,
• a G or an A at position 37114 in FIG. 2,
• an A or a C at position 37434 in FIG. 2,
• a T or a G at position 41112 in FIG. 2, and
• a G or an A at position 41172 in FIG. 2, and combinations thereof as well as their reverse complement.

A computer readable medium having stored thereon sequence information for the polymorphisms in the NKNA gene comprising polymorphisms in at least one of the following positions:

• at position 33612 as defined by the position in FIG. 2,
• at position 33949 as defined by the position in FIG. 2,
• at position 37025 as defined by the position in FIG. 2,
• at position 37114 as defined by the position in FIG. 2,
• at position 37434 as defined by the position in FIG. 2,
• at position 41112 as defined by the position in FIG. 2, and
• at position 41172 as defined by the position in FIG. 2.