Method for treating cerebral ishaemia

A method of treating cerebral ischaemia which method comprises administering to a host in need of such treatment a therapeutic amount of a compound of the Formula I

• 6
• wherein:
• A is a sulphur atom, oxygen atom,>NH or>N—C1-C4-alkyl;
• R1 is a group selected from the group consisting of hydrogen, C1-C6-alkyl optionally substituted by one or more halogen atoms, —SO2H, —SO2—C1-C6-alkyl, —SO—C1-C6-alkyl, —CO—C1-C6-alkyl, —O—, C1-C4-alkyl substituted by a phenyl, —C1-C4-alkyl-NR7R8, —C1-C4-alkyl-O—C1-C4-alkyl and, —C3-C6-cycloalkyl;
• R2and R9 are identical or different and each is a group selected from the group consisting of hydrogen, C1-C6-alkyl optionally substituted by one or more halogen atoms, halogen, —NO2, —SO2H, —SO2—C1-C6-alkyl, —SO—C1-C6-alkyl, —CO—C1-C6-alkyl, —OH, —O—C1-C6-alkyl, —S—C1-C6-alkyl, —C1-C4-alkyl-NR7R8, —C1-C4-alkyl-O—C1-C4 -alkyl and —C3-C6-cycloalkyl;
• or,
• R1 and R2 together form a C2-C6-alkylene bridge;
• R7 and R8 are identical or different and each is hydrogen or C1-C4-alkyl;
• and,
• R3, R4, R5 and R6 are identical or different and each is a group selected from the group consisting of hydrogen, C1-C6-alkyl optionally substituted by one or more halogen atoms, C1-C4-alkyl substituted by a phenyl, halogen, —CN, —NO2, —SO2H, —SO3H, —SO2—C1-C6-alkyl, —SO—C1-C6-alkyl, —SO2—NR7R8, —COOH, —CO—C1-C6-alkyl, —O—CO—C1-C4-alkyl, —CO—O—C1-C4-alkyl, —CO—NR7R8, —OH, —O—C1-C6-alkyl, —S—C1-C6-alkyl, —NR7R8 and aromatic ring systems having 6-10 carbon atoms (wherein one or more hydrogen atoms are optionally substituted by a halogen atom, —NO2, —SO2H or —C1-C4-alkyl);
• or a pharmacologically acceptable salt thereof.