Heterocyclic retinoid compounds

A compound according to structural formula (I):

• 57
• or a pharmaceutically acceptable salt, solvate or hydrate thereof wherein:
• n is an integer from 0 to 2;
• A is aryl or heteroaryl;
• Bis O, S or NR6;
• R is hydrogen or alkyl;
• Y is —OR7, —SR7 or —NR8R9;
• R7 is hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl;
• R8 and R9 are independently hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl or together with the nitrogen atom to which they are attached form a heterocycloamino ring;
• Z is —C(R101)2O—, —R102C═CR102—, —C≡C—, —C(R103)2S—, —C(O)O— or —C(O)NR10—;
• each of R10, R101, R102 and R103 is independently hydrogen or alkyl;
• R1 and R2 are independently hydrogen or alkyl;
• R3 is hydrogen or alkyl;
• and
• R4 and R5 are independently hydrogen, (C1-C8) alkyl or arylalkyl.