Neurotherapeutic composition and method therefor
OwnerGary A. Koppel, Michael O. Chaneyinventors
Life of this patent
Estimating the term…
Abstract
Neurotherapeutically pharmaceutical effective compositions are prepared using carboxypeptidase E inhibitors. One class of carboxypeptidase E inhibitors found to exhibit significant neurotropic activity are β-lactam compounds, particularly penam and cephem β-lactam antibiotics and non-antibiotic derivatives thereof.
Claims23
A method of manufacturing a pharmaceutical composition useful for treatment of behavioral disorders and enhancing cognitive function in patients in need of such therapy, said method comprising the steps of combining an inhibitor of carboxypeptidase E with a pharmaceutically acceptable carrier and forming a unit dosage form comprising a neurotherapeutically effective amount of the carboxypeptidase E inhibitor.
A neurotherapeutic pharmaceutical composition in unit dosage form comprising a neurotherapeutically effective amount of a carboxypeptidase E inhibitor with the proviso that when the carboxypeptidase E inhibitor is a β-lactam antibiotic, the neurotherapeutically effective amount of the carboxypeptidase E inhibitor in the unit dosage form is less than an antibiotically effective amount of the carboxypeptidase E inhibitor if such β- lactam antibiotic were to be administered in a unit dosage form designed for the same route of administration.
A neurotherapeutic pharmaceutical composition comprising a neurotherapeutically effective amount of a cephem sulfoxide and a pharmaceutically acceptable carrier thereof.
A neurotherapeutic pharmaceutical composition comprising a neurotherapeutically effective amount of a cephem sulfone and a pharmaceutically acceptable carrier thereof.
A neurotherapeutic pharmaceutical composition comprising a neurotherapeutically effective amount of a penam sulfoxide and a pharmaceutically acceptable carrier thereof.
A neurotherapeutic pharmaceutical composition comprising a neurotherapeutically effective amount of a penam sulfone and a pharmaceutically acceptable carrier thereof.
Dependencies are inferred from the claim text.