Composition for combined use of aromatase inhibitors
OwnerGiorgio Massimini, Dinesh Purandareinventors
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Abstract
A method of treating a human being suffering from an hormone-dependent disorder comprising administering to said human being a steroidal aromatase inhibitor e.g. exemestane of formestane and a non-steroidal aromatase inhibitor e.g. fadrozole or vorozole, in amounts effective to produce a superadditive therapeutic effect.
Claims16
Use of a steroidal aromatase inhibitor in the manufacture of a pharmaceutical composition for treatment of a sex steroid hormone-dependent disorder, the treatment additionally comprising the administration of a composition comprising a non-steroidal aromatase inhibitor, in amounts effective to produce a superadditive effect.
Product comprising a steroidal aromatase inhibitor and a non-steroidal aromatase inhibitor, as combined preparation for simultaneous, separate or sequential administration, in amounts to produce a synergistic or superadditive therapeutic activity against an hormone-dependent disorder.
A method of treating a human being, particularly a female, suffering from a sex steroid hormone-dependent disorder comprising administering to said human being a steroidal aromatase inhibitor and a non-steroidal aromatase inhibitor, in amounts effective to produce a superadditive or synergistic therapeutic effect.
A method of treating a human being, particularly a female, suffering from a sex steroid hormone-dependent disorder comprising administering to said human being a steroidal aromatase inhibitor and a non-steroidal aromatase inhibitor, in amounts effective to produce a superadditive or synergistic therapeutic effect and to prevent resistance phenomena.
A method for lowering the side effects (adverse reactions) caused by antitumor therapy with a steroidal aromatase inhibitor in a human being, particularly a female, suffering from a sex steroid hormone-dependent disorder, the method comprising administering to said human being a combined preparation comprising a steroidal aromatase inhibitor and a non-steroidal aromatase inhibitor, in amounts effective to produce a superadditive or synergistic antitumor effect, while controlling the growth of neoplasm formation.
A method for lowering the side effects (adverse reactions) caused by antitumor therapy with a non-steroidal aromatase inhibitor in a human being, particularly a female, suffering from a sex steroid hormone-dependent disorder, the method comprising administering to said human being a combined preparation comprising a non-steroidal aromatase inhibitor and a steroidal aromatase inhibitor, in amounts effective to produce a superadditive or synergistic antitumor effect, while controlling the growth of neoplasm formation.
Dependencies are inferred from the claim text.