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AssigneeResearch Institute for Medicine and Chemistry Inc.
InventorsRobert Henry Hesse, Sundara Katugam Srinivasasetty Setty, Maurice Murdoch Pechet, Michael Gile
Estimating the term…
Compounds of formula (I) in which: R1 represents a hydrogen atom or an O-protecting group; R2 represents a hydroxyl, lower alkoxy, carboxaldehyde, lower alk-1-enyl or hydroxy- or lower alkoxy-substituted lower alkyl group; R3 represents a methyl group having α- or β-configuration; X represents a C1-3 alkylene group or a valence bond; Y represents a carboxaldehyde group or a group of formula —C(R4)(R5)OR1 where R1 is as defined above and R4 and R5, which may be the same or different, are each selected from hydrogen atoms, alkyl, alkenyl and alkynyl groups such that the total carbon content of R4 and R5 does not exceed three atoms, with the proviso that X is a valence bond when both R4 and R5 are other than hydrogen; and the dotted line signifies that a double bond may optionally be present at the 16(17)-position exhibit potent cell modulating activity, including antiproliferative and antiangiogenic effects.
Compounds of formula (I)
Compounds as claimed in any of the preceding claims wherein each R1 is selected from hydrogen atoms, lower alkyl groups and metabolically labile O-protecting groups.
Compounds as claimed in any of the preceding claims wherein R2 is selected from methoxy, ethoxy, propoxy, vinyl, prop-1-enyl, but-1-enyl, hydroxymethyl, hydroxyethyl, hydroxypropyl, methoxymethyl, methoxyethyl, methoxypropyl, ethoxymethyl, ethoxyethyl and ethoxypropyl groups.
The compounds:
Active compounds of formula (I) as claimed in any of the preceding claims for use in management of neoplastic disease;
Dependencies are inferred from the claim text.