Back to results
US 2003/0158163 A1Published application
Organic compounds
AssigneeNovartis AG
InventorsBernard Cuenoud, David Beattie, Thomas Hugo Keller, Gaynor Elizabeth Pilgrim, David Andrew Sandham, Simon James Watson
Life of this patent
Estimating the term…
Abstract
Compounds of formula (I), where R is a monovalent cyclic organic group having from 3 to 15 atoms in the ring system, useful as pharmaceuticals.
Claims15
A compound of formula
- 106
- where R is a monovalent cyclic organic group having from 3 to 15 atoms in the ring system.
A compound of formula I
- 107
- where the indicated 16-methyl group has the alpha conformation and R is 5-methyl-2-thienyl, N-methyl-2-pyrrolyl, cyclopropyl, 2-furyl, 3-methyl-2-furyl, 3-methyl-2-thienyl, 5-methyl-3-isoxazolyl, 3,5-dimethyl-2-thienyl, 2,5-dimethyl-3-furyl, 4-methyl-2-furyl, 4-(dimethylamino)phenyl, 4-methylphenyl, 4-ethylphenyl, 2-pyridyl, 4pyrimidyl or 5-methyl-2-pyrazinyl or the indicated 16-methyl group has the beta conformation and R is cyclopropyl.
A process for the preparation of compounds of formula I which comprises
- (A) conversion of a carboxylic acid of formula
- 108
- where R is a monovalent cyclic organic group, or an ester-forming functional derivative thereof, into the methyl ester thereof;
- or
- (B) hydrochlorination of a compound of formula
- 109
- where R is a monovalent cyclic organic group.
4 more elements
Dependencies are inferred from the claim text.