Chemical compounds
AssigneeSmithKline Beecham Corporation
InventorsColin David Eldred, Andrew Michael Kenneth Pennell
Life of this patent
Estimating the term…
Abstract
A compound of formula (I), wherein R2 represents C1-3alkyl, halogen or hydrogen; R3 represents straight or branched alkyl group of 1-6 carbon atoms; with the proviso that, when R3 represents C1-3alkyl, R2 represents C1-3alkyl, R1 cannot represent phenyl optionally substituted by one or more substituents selected from halogen, C1-3alkyl, trifluoromethyl, nitro, cyano, —CO2Rc, —CONRcRd, —CORc, —SORe, —SO2Re, —SO3H, —SO2NRcRd, —ORc, —NHSO2Re, —NHCORc and —NRcRd; and salts and solvates thereof, in particular, physiologically acceptable solvates and salts thereof. These compounds are agonists at the Adenosine A1 receptor.
Claims22
A compound of formula (I):
- 8
- wherein R2 represents C1-3alkyl, halogen or hydrogen;
- R3 represents straight or branched alkyl group of 1-6 carbon atoms;
- R1 represents a group selected from:
- (1) -(alk)n-(C3-7)cycloalkyl, including bridged cycloalkyl, said cycloalkyl group optionally being substituted by one or more substituents selected from OH, halogen, and —(C1-3alkoxy), wherein (alk) represents C1-3alkylene and n represents 0 or 1;
- (2) an aliphatic heterocyclic group of 4 to 6 membered rings containing at least one heteroatom selected from O, N or S, optionally substituted by one or more substituents selected from the group consisting of —(C1-3)alkyl, —CO2—(C1-4)alkyl, —CO(C1-3alkyl), —S(═O)n—(C1-3alkyl), —CONRaRb (wherein Ra and Rb independently represent H or C1-3alkyl) and ═O;
- and where there is a sulfur atom in the heterocyclic ring, said sulfur is optionally substituted by (═O)n, where n is 1 or 2;
- (3) straight or branched C1-12 alkyl, optionally including one or more O, S(═O)n (where n is 0, 1 or 2), or N groups substituted within the alkyl chain, said alkyl being optionally substituted by one or more of the following groups:
- phenyl, halogen, hydroxy or NRaRb wherein Ra and Rb both represent C1-3alkyl or hydrogen;
- and physiologically acceptable solvates and salts thereof.
Dependencies are inferred from the claim text.