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OwnerInder M. Verma, Mark Schmitt +1inventors
InventorsInder M. Verma, Mark Schmitt, Nikunj V. Somia
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A substantially purified lifeguard (LFG) polypeptide is provided. The polypeptide includes an amino acid sequence as set forth in SEQ ID NO: 2, or a conservative variant thereof. An isolated polynucleotide is provided that encodes an amino acid sequence as set forth in SEQ ID NO: 2, or a conservative variant thereof. An antibody is provided that binds to a polypeptide having an amino acid sequence as set forth in SEQ ID NO: 2. A method is provided for identifying a compound which affects a function of a polypeptide as set forth in SEQ ID NO: 2, or a conservative variant thereof, or affects the expression of a polynucleotide comprising a sequence as set forth in SEQ ID NO: 1. A method is provided for treating a subject with a disorder associated with decreased or increased Fas-mediated cell death. A method is provided for treating a patient having or at risk of having a disorder associated with increased Fas-mediated cell death.
An antibody which binds to a polypeptide having an amino acid sequence as set forth in SEQ ID NO:
A method of screening for a compound which affects apoptosis, comprising:
A method of treating a subject with a disorder associated with decreased Fas-mediated cell death, comprising administering to the subject a therapeutically effective amount of a compound that inhibits the function of a protein having the amino acid sequence of SEQ ID NO:
A method of treating a subject with a disorder associated with increased Fas-mediated cell death, comprising administering to the subject a therapeutically effective of a compound that augments the function of a protein having the amino acid sequence of SEQ ID NO:
A method of treating a patient having or at risk of having a disorder associated with increased Fas-mediated cell death, comprising:
A kit for detecting the presence of LFG in a sample, the kit comprising carrier means being compartmentalized to receive therein one or more containers comprising a container containing an antibody which specifically binds to a protein having the amino acid sequence of SEQ ID NO:
A kit useful for the detection of a target LFG nucleic acid sequence, the kit comprising carrier means being compartmentalized to receive therein one or more containers comprising a container containing oligonucleotides which hybridize to a nucleic acid having the nucleotide sequence of SEQ ID NO:
A transgenic nonhuman animal having a phenotype characterized by expression of LFG, otherwise not naturally occurring in the animal, the phenotype being conferred by a transgene contained in the somatic and germ cells of the animal, the transgene comprising a nucleic acid sequence which encodes the amino acid sequence of SEQ ID NO:
Dependencies are inferred from the claim text.