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US 2003/0158137 A1Published application
Gene directed enzyme prodrug theraphy (gdept) for cell ablation
OwnerDonald Daviesinventor
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Abstract
The invention relates to a method of gene directed enzyme pro-drug therapy (GDEPT) in the ablation of cells wherein said cells are not cancerous cells.
Claims28
A method to specifically ablate cells, wherein said cells are not cancer cells, comprising:
- i) administering to a mammal an effective amount of a vector capable of transfecting a cell wherein the vector includes at least one P450 gene, or an effective part thereof, the expression of which is controlled by a promoter sequence, or the effective part thereof, which shows substantially cell specific expression;
- and
- ii) administering a therapeutically effective amount of acetaminophen, or a structurally related derivative thereof
A method to specifically ablate cells, wherein said cells are not cancer cells, comprising:
- i) administering to a mammal an effective amount of a vector capable of transfecting a cell wherein the vector includes at least one P450 gene, or an effective part thereof, the expression of which is controlled by a promoter sequence, or the effective part thereof, which shows substantially cell specific expression;
- ii) administering an effective amount of at least one agent capable of modulating the amount of gluthathione in the liver of said mammal;
- and
- iii) administering a therapeutically effective amount of acetaminophen, or a structurally related variant thereof.
1 more element
Dependencies are inferred from the claim text.