Vaccine for the prophylactic or therapeutic immunization against hiv
OwnerGerald Vossinventor
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Abstract
The invention provides the use of a) an HIV Tat protein or polynucleotide; or b) an HIV Nef protein or polynucleotide; or c) an HIV Tat protein or polynucleotide linked to an HIV Nef protein or polynucleotide (Nef-Tat); and an HIV gpl20 protein or polynucleotide in the manufacture of a vaccine for the prophylactic or therapeutic immunisation of humans against HIV.
Claims24
Use of a) an HIV Tat protein or polynucleotide;
- or
- b) an HIV Nef protein or polynucleotide;
- or
- c) an HIV Tat protein or polynucleotide linked to an HIV Nef protein or polynucleotide (Nef-Tat);
- and an HIV gp120 protein or polynucleotide in the manufacture of a vaccine for the prophylactic or therapeutic immunisation of humans against HIV, wherein the Tat, Nef or Nef-Tat act in synergy with gp120 in the treatment or prevention of HIV.
Use of a) an HIV Tat protein or polynucleotide;
- or
- b) an HIV Nef protein or polynucleotide;
- or
- c) an HIV Tat protein or polynucleotide linked to an HIV Nef protein or polynucleotide;
- and an HIV gp120 protein or polynucleotide in the manufacture of a vaccine suitable for a prime-boost delivery for the prophylactic or therapeutic immunisation of humans against HIV.
A method of immunising a human against HIV by administering to the human a vaccine comprising HIV Tat or HIV Nef or HIV NefTat in combination with HIV gp120 proteins or polynucleotides encoding them.
A vaccine composition for human use which vaccine composition comprises HIV Tat or HIV Nef or HIV Nef-Tat in combination with HIV gp120 proteins or polynucleotides encoding them.
19 A schedule for vaccination with gp120, nef and tat comprising the sequential administration of protein antigens and DNA encoding gp120, nef and tat.
20 A schedule according to claim 19, wherein the protein antigens are injected once or several times followed by one or more DNA administrations.
21 A schedule according to claim 19 wherein the DNA is used first for one or more administrations followed by one or more protein administrations.
22 Use of
- (a) a composition comprising gp120 Nef, Tat and gp120 proteins;
- and
- (b) a composition comprising gp120, Nef and Tat DNA
- in the preparation of a medicament for treatment of HIV, wherein (a) and (b) may be used separately, in any order or together.
23 Use of gp120, nef and tat protein antigens in the preparation of a medicament for the treatment of HIV in an individual to whom DNA encoding gp120, nef and tat protein antigens has been administered.
24 Use of DNA encoding gp120, nef and tat protein antigens in the preparation of a medicament for the treatment of HIV in an individual to whom gp120, nef and tat protein antigens have been administered.
Dependencies are inferred from the claim text.